Aging is associated with reductions in hippocampal volume that are accelerated by Alzheimer's disease and vascular risk factors. Our genome-wide association study (GWAS) of dementia-free persons (n = 9,232) identified 46 SNPs at four loci with P values of <4.0 × 10
| Verfasser: |
Bis, J.C.
DeCarli, C.S.
Vernon Smith, A.
van der Lijn, F.
Crivello, F.
Fornage, M.
Debette, S.
Shulman, J.M.
Schmidt, H.
Srikanth, V.
Schuur, M.
Yu, L.
Choi, S.
Sigurdsson, S.
Verhaaren, B.F.J.
DeStefano, A.L.
Lambert, J.C.
Jack, C.R., Jr.
Struchalin, M.
Stankovich, J.
Ibrahim-Verbaas, C.A.
Fleischman, D.
Zijdenbos, A.
den Heijer, T.
Mazoyer, B.
Coker, L.H.
Enzinger, C.
Danoy, P.
Amin, N.
Arfanakis, K.
van Buchem, M.A.
de Bruijn, R.F.A.G.
Beiser, A.
Dufouil, C.
Huang, J.
Cavalieri, M.
Thomson, R.
Niessen, W.J.
Chibnik, L.B.
Gislason, G.K.
Hofman, A.
Pikula, A.
Amouyel, P.
Freeman, K.B.
Phan, T.G.
Oostra, B.A.
Stein, J.L.
Medland, S.E.
Vasquez, A.A.
Hibar, D.P.
Wright, M.J.
Franke, B.
Martin, N.G.
Thompson, P.M.
Hottenga, J.J.
Boomsma, D.I.
Nalls, M.A.
Uitterlinden, A.G.
Au, R.
Elbaz, A.
Beare, R.J.
van Swieten, J.C.
Lopez, O.L.
Harris, T.B.
Chouraki, V.
Breteler, M.M.B.
de Jager, P.L.
Becker, J.T.
Vernooij, M.W.
Knopman, D.
Fazekas, F.
Wolf, P.A.
van der Lugt, A.
Gudnason, V.
Longstreth, Jr. W.T.
Brown, M.A.
Bennett, D.A.
van Duijn, C.M.
Mosley, T.H.
Schmidt, R.
Tzourio, C.
Launer, L.J.
Arfan Ikram, M.
Seshadri, S. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2012 |
| Reihe/Periodikum: |
Bis , J C , DeCarli , C S , Vernon Smith , A , van der Lijn , F , Crivello , F , Fornage , M , Debette , S , Shulman , J M , Schmidt , H , Srikanth , V , Schuur , M , Yu , L , Choi , S , Sigurdsson , S , Verhaaren , B F J , DeStefano , A L , Lambert , J C , Jack , C R J , Struchalin , M , Stankovich , J , Ibrahim-Verbaas , C A , Fleischman , D , Zijdenbos , A , den Heijer , T , Mazoyer , B , Coker , L H , Enzinger , C , Danoy , P , Amin , N , Arfanakis , K , van Buchem , M A , de Bruijn , R F A G , Beiser , A , Dufouil , C , Huang , J , Cavalieri , M , Thomson , R , Niessen , W J , Chibnik , L B , Gislason , G K , Hofman , A , Pikula , A , Amouyel , P , Freeman , K B , Phan , T G , Oostra , B A , Stein , J L , Medland , S E , Vasquez , A A , Hibar , D P , Wright , M J , Franke , B , Martin , N G , Thompson , P M , Hottenga , J J , Boomsma , D I , Nalls , M A , Uitterlinden , A G , Au , R , Elbaz , A , Beare , R J , van Swieten , J C , Lopez , O L , Harris , T B , Chouraki , V , Breteler , M M B , de Jager , P L , Becker , J T , Vernooij , M W , Knopman , D , Fazekas , F , Wolf , P A , van der Lugt , A , Gudnason , V , Longstreth , J W T , Brown , M A , Bennett , D A , van Duijn , C M , Mosley , T H , Schmidt , R , Tzourio , C , Launer , L J , Arfan Ikram , M & Seshadri , S 2012 , ' Common variants at 12q14 and 12q24 are associated with hippocampal volume ' , Nature Genetics , vol. 44 , no. 5 , pp. 545-551 . https://doi.org/10.1038/ng.2237 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-27231170 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/589f4044-20c1-43aa-8b68-1e746f02e1ef |
