Using a genome-wide screen of 9.6 million genetic variants achieved through 1000 Genomes Project imputation in 62,166 samples, we identify association to lipid traits in 93 loci, including 79 previously identified loci with new lead SNPs and 10 new loci, 15 loci with a low-frequency lead SNP and 10 loci with a missense lead SNP, and 2 loci with an accumulation of rare variants. In six loci, SNPs with established function in lipid genetics (CELSR2, GCKR, LIPC and APOE) or candidate missense mutations with predicted damaging function (CD300LG and TM6SF2) explained the locus associations. The low... Mehr ...
Verfasser: |
Surakka, I.
Horikoshi, M.
Magi, R.
Sarin, A.
Mahajan, A.
Lagou, V.
Marullo, L.
Ferreira, T.
Miraglio, B.
Timonen, S.
Kettunen, J.
Pirinen, M.
Karjalainen, J.
Thorleifsson, G.
Hagg, S.
Hottenga, J.J.
Isaacs, A.
Ladenvall, C.
Beekman, M.
Esko, T.
Ried, J.S.
Nelson, C.P.
Willenborg, C.
Gustafsson, S.
Westra, H.
Blades, M.
Craen, A.J.M.
de Geus, E.J.C.
Deelen, J.
Grallert, H.
Hamsten, A.
Havulinna, A.S.
Hengstenberg, C.
Houwing-Duistermaat, J.J.
Hypponen, E.
Karssen, L.C.
Lehtimaki, T.
Lyssenko, V.
Magnusson, P.K.E.
Mihailov, E.
Muller-Nurasyid, M.
Mpindi, J.
Pedersen, N.L.
Penninx, B.W.J.H.
Perola, M.
Pers, T.H.
Peters, A.
Rung, J.
Smit, J.H.
Steinthorsdottir, V.
Tobin, M.D.
Tsernikova, N.
van Leeuwen, E.M.
Viikari, J.S.
Willems, S.M.
Willemsen, G.
Schunkert, H.
Erdmann, J.
Samani, N.J.
Kaprio, J.
Lind, L.
Gieger, C.
Metspalu, A.
Slagboom, P.E.
Groop, L.
van Duijn, C.M.
Eriksson, J.G.
Jula, A.
Salomaa, V.
Boomsma, D.I.
Power, C.
Raitakari, O.T.
Ingelsson, E.
Jarvelin, M.
Thorsteinsdottir, U.
Franke, L.
Ikonen, E.
Kallioniemi, O.
Pietiainen, V.
Lindgren, C.M.
Stefansson, K.
Palotie, A.
McCarthy, M.I.
Morris, A.P.
Prokopenko, I.
Ripatti, S. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2015 |
Reihe/Periodikum: |
Surakka , I , Horikoshi , M , Magi , R , Sarin , A , Mahajan , A , Lagou , V , Marullo , L , Ferreira , T , Miraglio , B , Timonen , S , Kettunen , J , Pirinen , M , Karjalainen , J , Thorleifsson , G , Hagg , S , Hottenga , J J , Isaacs , A , Ladenvall , C , Beekman , M , Esko , T , Ried , J S , Nelson , C P , Willenborg , C , Gustafsson , S , Westra , H , Blades , M , Craen , A J M , de Geus , E J C , Deelen , J , Grallert , H , Hamsten , A , Havulinna , A S , Hengstenberg , C , Houwing-Duistermaat , J J , Hypponen , E , Karssen , L C , Lehtimaki , T , Lyssenko , V , Magnusson , P K E , Mihailov , E , Muller-Nurasyid , M , Mpindi , J , Pedersen , N L , Penninx , B W J H , Perola , M , Pers , T H , Peters , A , Rung , J , Smit , J H , Steinthorsdottir , V , Tobin , M D , Tsernikova , N , van Leeuwen , E M , Viikari , J S , Willems , S M , Willemsen , G , Schunkert , H , Erdmann , J , Samani , N J , Kaprio , J , Lind , L , Gieger , C , Metspalu , A , Slagboom , P E , Groop , L , van Duijn , C M , Eriksson , J G , Jula , A , Salomaa , V , Boomsma , D I , Power , C , Raitakari , O T , Ingelsson , E , Jarvelin , M , Thorsteinsdottir , U , Franke , L , Ikonen , E , Kallioniemi , O , Pietiainen , V , Lindgren , C M , Stefansson , K , Palotie , A , McCarthy , M I , Morris , A P , Prokopenko , I & Ripatti , S 2015 , ' The impact of low-frequency and rare variants on lipid levels ' , Nature Genetics , vol. 47 , no. 6 , pp. 589-597 . https://doi.org/10.1038/ng.3300 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27231108 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/4b9ce72a-0ff1-4bf9-852a-47c68a349cbe |