European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation
Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date (discovery N = 1,086,394, replication N = 3,604,027), combining previously reported cohorts with additional available data. We identified 81 loci (29 novel) in the European-only analysis (which all replicated in a separate European analysis) and 10 additional loci in the multi-ancestry analysis (3 novel). Eight variants from the multi-ancestry analysis replicated in at least one of the p... Mehr ...
Verfasser: |
Budu-Aggrey, Ashley
Kilanowski, Anna
Sobczyk, Maria K.
Shringarpure, Suyash S.
Mitchell, Ruth
Boomsma, Dorret I.
Hottenga, Jouke J.
Holloway, John W.
Min, Josine L.
Brown, Sara J.
Standl, Marie
Paternoster, Lavinia |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2023 |
Reihe/Periodikum: |
Budu-Aggrey , A , Kilanowski , A , Sobczyk , M K , Shringarpure , S S , Mitchell , R , Boomsma , D I , Hottenga , J J , Holloway , J W , Min , J L , Brown , S J , Standl , M , Paternoster , L & 23 and Me Research Team 2023 , ' European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation ' , Nature Communications , vol. 14 , 6172 , pp. 1-18 . https://doi.org/10.1038/s41467-023-41180-2 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27230292 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/cc0396bf-70a9-41db-91e3-8cc10d30ffc1 |