Common variants in TMPRSS6 are associated with iron status and erythrocyte volume
We report a genome-wide association study to iron status. We identify an association of SNPs in TPMRSS6 to serum iron (rs855791, combined P = 1.5 × 10 20), transferrin saturation (combined P = 2.2 × 10 23) and erythrocyte mean cell volume (MCV, combined P = 1.1 × 10 10). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 × 10 7). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis. © 2009 Nature America, Inc. All rights reserved.
Verfasser: |
Benyamin, B.
Ferreira, M.A.
Willemsen, G.
Gordon, S.
Middelberg, R.P.S.
McEvoy, B.P.
Hottenga, J.J.
Henders, A.K.
Campbell, MJ
Wallace, L.
Frazer, I.H.
Heath, A.C.
de Geus, E.J.C.
Nyholt, DR
Visscher, P.M.
Penninx, B.W.J.H.
Boomsma, D.I.
Martin, N.G.
Montgomery, GW
Whitfield, J.B. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2009 |
Reihe/Periodikum: |
Benyamin , B , Ferreira , M A , Willemsen , G , Gordon , S , Middelberg , R P S , McEvoy , B P , Hottenga , J J , Henders , A K , Campbell , MJ , Wallace , L , Frazer , I H , Heath , A C , de Geus , E J C , Nyholt , DR , Visscher , P M , Penninx , B W J H , Boomsma , D I , Martin , N G , Montgomery , GW & Whitfield , J B 2009 , ' Common variants in TMPRSS6 are associated with iron status and erythrocyte volume ' , Nature Genetics , vol. 41 , no. 11 , pp. 1173-1175 . https://doi.org/10.1038/ng.456 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27230173 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/c037d6ee-4b3b-48cf-9128-a9dfb6b81753 |