Major depressive disorder (MDD) is a common complex disorder with a partly genetic etiology. We conducted a genome-wide association study of the MDD2000 sample (2431 cases, 3673 screened controls and 1 M imputed single-nucleotide polymorphisms (SNPs)). No SNPs achieved genome-wide significance either in the MDD2000 study, or in meta-analysis with two other studies totaling 5763 cases and 6901 controls. These results imply that common variants of intermediate or large effect do not have main effects in the genetic architecture of MDD. Suggestive but notable results were (a) gene-based tests sug... Mehr ...
| Verfasser: |
Wray, N.R.
Pergadia, M.L.
Blackwood, D.H.
Penninx, B.W.J.H.
Gordon, S.D.
Nyholt, DR
Ripke, S.
MacIntyre, D.J.
McGhee, K.A.
Maclean, A. W.
Smit, J.H.
Hottenga, J.J.
Willemsen, G.
Middeldorp, C.M.
de Geus, E.J.C.
Lewis, C.M.
McGuffin, P.
Hickie, I.B.
van den Oord, E.J.C.G.
Liu, J.Z.
Macgregor, S.
McEvoy, B.P.
Byrne, E.M.
Medland, S.E.
Statham, D.J.
Henders, A.K.
Heath, A.C.
Montgomery, G.W.
Martin, N.G.
Boomsma, D.I.
Madden, P.A.F.
Sullivan, P.F. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2012 |
| Reihe/Periodikum: |
Wray , N R , Pergadia , M L , Blackwood , D H , Penninx , B W J H , Gordon , S D , Nyholt , DR , Ripke , S , MacIntyre , D J , McGhee , K A , Maclean , A W , Smit , J H , Hottenga , J J , Willemsen , G , Middeldorp , C M , de Geus , E J C , Lewis , C M , McGuffin , P , Hickie , I B , van den Oord , E J C G , Liu , J Z , Macgregor , S , McEvoy , B P , Byrne , E M , Medland , S E , Statham , D J , Henders , A K , Heath , A C , Montgomery , G W , Martin , N G , Boomsma , D I , Madden , P A F & Sullivan , P F 2012 , ' Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned ' , Molecular Psychiatry , vol. 17 , no. 1 , pp. 36-48 . https://doi.org/10.1038/mp.2010.109 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-27229900 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/ab4524f4-326e-4093-b73c-314dcfd4f4d3 |
