Two-locus linkage analysis applied to putative quantitative trait loci for Lp(a) levels
Plasma levels of lipoprotein(a) - Lp(a) - are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs.
| Verfasser: |
Beekman, M.
Heijmans, B.T.
Martin, N.G.
Whitfield, J.B.
Pedersen, N.L.
DeFaire, U.
Snieder, H.
Lakenberg, N.
de Knijff, P.
Frants, R.R.
van Ommen, G.J.B
Kluft, C.
Vogler, G.P.
Slagboom, P.E.
Boomsma, D.I. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2003 |
| Reihe/Periodikum: |
Beekman , M , Heijmans , B T , Martin , N G , Whitfield , J B , Pedersen , N L , DeFaire , U , Snieder , H , Lakenberg , N , de Knijff , P , Frants , R R , van Ommen , G J B , Kluft , C , Vogler , G P , Slagboom , P E & Boomsma , D I 2003 , ' Two-locus linkage analysis applied to putative quantitative trait loci for Lp(a) levels ' , Twin Research , vol. 6 , no. 4 , pp. 322-324 . https://doi.org/10.1375/136905203322296692 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-27229670 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/8e76ba64-c2fe-41f0-b235-de21f152c2db |
