WHITE MATTER MICROSTRUCTURE AND AMYLOID AGGREGATION IN COGNITIVELY HEALTHY, ELDERLY IDENTICAL TWINS
Background: Lack of effective predictive models and/or treatments for Alzheimer's Disease (AD) has led a growing movement towards better characterization of pre-clinical stages. One currently established biomarker is positron emission tomography (PET) measured amyloid beta load. Here, in a genetically informative population of cognitively healthy, elderly identical twins, we compared this biomarker to a promising new candidate; white matter (WM) integrity measured by diffusion tensor imaging (DTI). Method(s): Eighty-eight genetically identical twin-pairs and 14 individual twins (n=190, mean ag... Mehr ...
Verfasser: |
den Braber, Anouk
Stickney, Kristine
van 't Ent, Dennis
ten Kate, Mara
Konijnenberg, Elles
Tomassen, Jori
Barkhof, Frederik
van Berckel, Bart N.M.
Boomsma, Dorret I.
de Geus, Eco
Scheltens, Philip
Visser, Pieter Jelle |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2018 |
Reihe/Periodikum: |
den Braber , A , Stickney , K , van 't Ent , D , ten Kate , M , Konijnenberg , E , Tomassen , J , Barkhof , F , van Berckel , B N M , Boomsma , D I , de Geus , E , Scheltens , P & Visser , P J 2018 , ' WHITE MATTER MICROSTRUCTURE AND AMYLOID AGGREGATION IN COGNITIVELY HEALTHY, ELDERLY IDENTICAL TWINS ' , Alzheimers & Dementia , vol. 14 , no. 7S Part 8 , P1-418 , pp. P465-P465 . https://doi.org/10.1016/j.jalz.2018.06.427 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27229648 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/8c7cc830-377e-42bc-ba1c-454e1b85d8b4 |