Genetic and environmental contributions to childhood obsessive behavior: A cross-cultural twin study.
Context: We have reported elsewhere on the development of an 8-item Obsessive-Compulsive Scale (OCS) contained in the Child Behavior Checklist (CBCL) to identify children who meet criteria for DSM-IV obsessive-compulsive disorder. Twin studies of obsessive-compulsive disorder have indicated a significant genetic component to its expression. Objective: To determine the relative contributions of genetic and environmental influences on childhood obsessive-compulsive behavior using the CBCL OCS in twin samples. Design: The CBCL data were received by survey of twins in the Netherlands Twin Registry... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2004 |
Reihe/Periodikum: | Hudziak , J , van Beijsterveldt , C E M , Althoff , R , Stanger , C , Rettew , D C , Nelson , E , Todd , R D , Bartels , M & Boomsma , D I 2004 , ' Genetic and environmental contributions to childhood obsessive behavior: A cross-cultural twin study. ' , Archives of General Psychiatry , vol. 61 , no. 6 , pp. 608-616 . https://doi.org/10.1001/archpsyc.61.6.608 |
Schlagwörter: | /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27229494 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://research.vu.nl/en/publications/7b2671da-fd5d-445e-8bf7-00c8c756e335 |
Context: We have reported elsewhere on the development of an 8-item Obsessive-Compulsive Scale (OCS) contained in the Child Behavior Checklist (CBCL) to identify children who meet criteria for DSM-IV obsessive-compulsive disorder. Twin studies of obsessive-compulsive disorder have indicated a significant genetic component to its expression. Objective: To determine the relative contributions of genetic and environmental influences on childhood obsessive-compulsive behavior using the CBCL OCS in twin samples. Design: The CBCL data were received by survey of twins in the Netherlands Twin Registry (NTR) and the Missouri Twin Study (USA/MOTWIN). Setting: General community twin samples. Participants: Participants were 4246 twin pairs aged 7 years, 2841 aged 10 years, and 1562 aged 12 years (who also participated in the study at 7 and 10 years of age) from the NTR and 1461 mixed-age twin pairs (average age, approximately 9 years) from the USA/MOTWIN. Main Outcome Measures: Model fitting to test for genetic and environmental influences, sex differences, and sibling interaction/rater contrast effects on the CBCL OCS. Results: In each case, the best-fitting model was one that indicated significant additive genetic influences (range, 45%-58%; 95% confidence interval [CI], 45%-61%), and unique environmental influences (range, 42%-55%; 95% CI, 39%-55%), with shared environmental influences in the NTR sample aged 12 years (16%). Sex differences were seen in the mixed-age USA/MOTWIN model, but not in the NTR samples. No evidence of dominance, sibling interaction, or rater-contrast effects was seen. These data were relatively consistent across age and cultures. Conclusions: The CBCL OCS is influenced by genetic factors (approximately 55%) and unique environmental factors (approximately 45%) in the younger sample, with common environmental influences only at 12 years of age. These effects do not vary with differences in sex or sibling interaction/rater contrast effects. Our data reveal higher genetic influences for ...