Inference of the Genetic Architecture Underlying BMI and Height with the Use of 20,240 Sibling Pairs
Evidence that complex traits are highly polygenic has been presented by population-based genome-wide association studies (GWASs) through the identification of many significant variants, as well as by family-based de novo sequencing studies indicating that several traits have a large mutational target size. Here, using a third study design, we show results consistent with extreme polygenicity for body mass index (BMI) and height. On a sample of 20,240 siblings (from 9,570 nuclear families), we used a within-family method to obtain narrow-sense heritability estimates of 0.42 (SE = 0.17, p = 0.01... Mehr ...
Verfasser: |
Hemani, G.
Yang, J.
Vinkhuyzen, A.A.E.
Powell, J.E.
Willemsen, G.
Hottenga, J.J.
Abdellaoui, A.
Mangino, M.
Valdes, A.M.
Medland, S.E.
Madden, P.A.F.
Heath, A.C.
Henders, A.K.
Nyholt, DR
de Geus, E.J.C.
Magnusson, P.K.E.
Ingelsson, E.
Montgomery, G.W.
Spector, T.D.
Boomsma, D.I.
Pedersen, N.L.
Martin, N.G.
Visscher, P.M. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2013 |
Reihe/Periodikum: |
Hemani , G , Yang , J , Vinkhuyzen , A A E , Powell , J E , Willemsen , G , Hottenga , J J , Abdellaoui , A , Mangino , M , Valdes , A M , Medland , S E , Madden , P A F , Heath , A C , Henders , A K , Nyholt , DR , de Geus , E J C , Magnusson , P K E , Ingelsson , E , Montgomery , G W , Spector , T D , Boomsma , D I , Pedersen , N L , Martin , N G & Visscher , P M 2013 , ' Inference of the Genetic Architecture Underlying BMI and Height with the Use of 20,240 Sibling Pairs ' , American Journal of Human Genetics , vol. 93 , no. 5 , pp. 865-875 . https://doi.org/10.1016/j.ajhg.2013.10.005 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27229336 |
Datenquelle: |
BASE;
Originalkatalog |
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BASE |
Link(s) :
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https://research.vu.nl/en/publications/6739b343-565e-41d1-b6d3-c876acb329a2 |