Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors

Observational studies have reported different effects of adiposity on cardiovascular risk factors across age and sex. Since cardiovascular risk factors are enriched in obese individuals, it has not been easy to dissect the effects of adiposity from those of other risk factors. We used a Mendelian randomization approach, applying a set of 32 genetic markers to estimate the causal effect of adiposity on blood pressure, glycemic indices, circulating lipid levels, and markers of inflammation and liver disease in up to 67,553 individuals. All analyses were stratified by age (cutoff 55 years of age)... Mehr ...

Verfasser:	Fall, T. Hägg, S. Ploner, A. Mägi, R. Fischer, K. Draisma, H.H.M. Sarin, A.-P. Benyamin, B. Ladenvall, C. Akerlund, M. Kals, M. Esko, T. Nelson, C.P. Kaakinen, M. Huikari, V. Mangino, M. Meirhaeghe, A. Kristiansson, K. Nuotio, M.L. Kobl, M. Grallert, H. Dehghan, A. Kuningas, M. de Vries, P.S. de Bruijn, R.F.A.G. Willems, S.M. Heikkilä, K. Silventoinen, K. Pietilainen, K.H. Legry, V. Giedraitis, V. Goumidi, L. Syvänen, A.C. Strauch, K. Koenig, W. Lichtner, P. Herder, C. Palotie, A. Menni, C. Uitterlinden, A.G. Kuulasmaa, K. Havulinna, A.S. Moreno, L.A. Gonzalez-Gross, M. Evans, A. Tregouet, D.A. Yarnell, J.W. Virtamo, J. Ferrières, J. Veronesi, G. Perola, M. Arveiler, D. Brambilla, P. Lind, L. Kaprio, J. Hofman, A. Stricker, B.H. van Duijn, C.M. Arfan Ikram, M. Franco, O.H. Cottel, D. Dallongeville, J. Hall, A.S. Jula, A. Tobin, M.D. Penninx, B.W.J.H. Peters, A. Gieger, C. Samani, N.J. Montgomery, G.W. Whitfield, J.B. Martin, N.G. Groop, L. Spector, T.D. Magnusson, P.K. Amouyel, P. Boomsma, D.I. Nilsson, P.M. Järvelin, M.R. Lyssenko, V. Metspalu, A. Strachan, D.P. Salomaa, V. Ripatti, S. Pedersen, N.L. Prokopenko, I. McCarthy, M.I. Ingelsson, E.
Dokumenttyp:	Artikel
Erscheinungsdatum:	2015
Reihe/Periodikum:	Fall , T , Hägg , S , Ploner , A , Mägi , R , Fischer , K , Draisma , H H M , Sarin , A-P , Benyamin , B , Ladenvall , C , Akerlund , M , Kals , M , Esko , T , Nelson , C P , Kaakinen , M , Huikari , V , Mangino , M , Meirhaeghe , A , Kristiansson , K , Nuotio , M L , Kobl , M , Grallert , H , Dehghan , A , Kuningas , M , de Vries , P S , de Bruijn , R F A G , Willems , S M , Heikkilä , K , Silventoinen , K , Pietilainen , K H , Legry , V , Giedraitis , V , Goumidi , L , Syvänen , A C , Strauch , K , Koenig , W , Lichtner , P , Herder , C , Palotie , A , Menni , C , Uitterlinden , A G , Kuulasmaa , K , Havulinna , A S , Moreno , L A , Gonzalez-Gross , M , Evans , A , Tregouet , D A , Yarnell , J W , Virtamo , J , Ferrières , J , Veronesi , G , Perola , M , Arveiler , D , Brambilla , P , Lind , L , Kaprio , J , Hofman , A , Stricker , B H , van Duijn , C M , Arfan Ikram , M , Franco , O H , Cottel , D , Dallongeville , J , Hall , A S , Jula , A , Tobin , M D , Penninx , B W J H , Peters , A , Gieger , C , Samani , N J , Montgomery , G W , Whitfield , J B , Martin , N G , Groop , L , Spector , T D , Magnusson , P K , Amouyel , P , Boomsma , D I , Nilsson , P M , Järvelin , M R , Lyssenko , V , Metspalu , A , Strachan , D P , Salomaa , V , Ripatti , S , Pedersen , N L , Prokopenko , I , McCarthy , M I & Ingelsson , E 2015 , ' Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors ' , Diabetes , vol. 64 , no. 5 , pp. 1841-1852 . https://doi.org/10.2337/db14-0988
Schlagwörter:	/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache:	Englisch
Permalink:	https://search.fid-benelux.de/Record/base-27228739
Datenquelle:	BASE; Originalkatalog
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Link(s) :	https://research.vu.nl/en/publications/2ee30698-429f-4ed9-8cd7-cdb20ba67d26