The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements t... Mehr ...

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Verfasser: Grasby, Katrina L
Armstrong, Nicola J
Brouwer, Rachel M
den Braber, Anouk
Fedko, Iryna O
Ford, Judith M
Heslenfeld, Dirk J
Hottenga, Jouke-Jan
Jansen, Iris E
Milaneschi, Yuri
Davies, Gareth E
Boomsma, Dorret I
de Geus, Eco J C
Oosterlaan, Jaap
Penninx, Brenda W J H
Polderman, Tinca J C
Posthuma, Danielle
van 't Ent, Dennis
Medland, Sarah E
Dokumenttyp: Artikel
Erscheinungsdatum: 2020
Reihe/Periodikum: Grasby , K L , Armstrong , N J , Brouwer , R M , den Braber , A , Fedko , I O , Ford , J M , Heslenfeld , D J , Hottenga , J-J , Jansen , I E , Milaneschi , Y , Davies , G E , Boomsma , D I , de Geus , E J C , Oosterlaan , J , Penninx , B W J H , Polderman , T J C , Posthuma , D , van 't Ent , D , Medland , S E & Alzheimer’s Disease Neuroimaging Initiative 2020 , ' The genetic architecture of the human cerebral cortex ' , Science , vol. 367 , no. 6484 , eaay6690 , pp. 1-14 . https://doi.org/10.1126/science.aay6690
Schlagwörter: /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR)
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-27228647
Datenquelle: BASE; Originalkatalog
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Link(s) : https://research.vu.nl/en/publications/24e85212-901f-4109-a8bc-9246e70bb73d