Analysis of shared heritability in common disorders of the brain
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of... Mehr ...
Verfasser: |
Ligthart, Lannie
Hottenga, Jouke Jan
Penninx, Brenda
Boomsma, Dorret
Middeldorp, Christel M.
Jansen, Rick
De Geus, Eco
Beekman, Aartjan T.F.
Derks, Eske M. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2018 |
Reihe/Periodikum: |
Ligthart , L , Hottenga , J J , Penninx , B , Boomsma , D , Middeldorp , C M , Jansen , R , De Geus , E , Beekman , A T F , Derks , E M & The Brainstorm Consortium 2018 , ' Analysis of shared heritability in common disorders of the brain ' , Science , vol. 360 , no. 6395 , eaap8757 , pp. 1-15 . https://doi.org/10.1126/science.aap8757 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27228496 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/13c21fc4-a49a-415a-81c1-4bd1e5f67ae4 |