Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case-control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP. As there is considerable genetic... Mehr ...
| Verfasser: |
Witt, S.H.
Streit, F.
Jungkunz, M
Frank, J.
Awasthi, S
Reinbold, C S
Treutlein, J.
Degenhardt, F.
Forstner, A. J.
Heilmann-Heimbach, S.
Dietl, L
Schwarze, C E
Schendel, D.J.
Strohmaier, J.
Abdellaoui, A
Adolfsson, R
Air, T M
Akil, H.
Lopezz de Alda, M.
Alliey-Rodriguez, N
Andreassen, O. A.
Babadjanova, G
Bass, N.J.
Bauer, M.
Baune, Bernard T
Bellivier, F.
Bergen, S. E.
Bethell, A.
Biernacka, J.M.
Blackwood, D H R
Boks, Marco P
Boomsma, D I
Børglum, Anders D
Borrmann-Hassenbach, M
Brennan, P.
Budde, M.
Buttenschøn, H N
Byrne, Enda M
Cervantes, P
Clarke, T.K.
Craddock, N.
Cruceanu, C
Curtis, D.
de Geus, E J C
Fischer, S B
Hottenga, J-J
Middeldorp, C M
Milaneschi, Y
Penninx, B W J H
Willemsen, G |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2017 |
| Reihe/Periodikum: |
Witt , S H , Streit , F , Jungkunz , M , Frank , J , Awasthi , S , Reinbold , C S , Treutlein , J , Degenhardt , F , Forstner , A J , Heilmann-Heimbach , S , Dietl , L , Schwarze , C E , Schendel , D J , Strohmaier , J , Abdellaoui , A , Adolfsson , R , Air , T M , Akil , H , Lopezz de Alda , M , Alliey-Rodriguez , N , Andreassen , O A , Babadjanova , G , Bass , N J , Bauer , M , Baune , B T , Bellivier , F , Bergen , S E , Bethell , A , Biernacka , J M , Blackwood , D H R , Boks , M P , Boomsma , D I , Børglum , A D , Borrmann-Hassenbach , M , Brennan , P , Budde , M , Buttenschøn , H N , Byrne , E M , Cervantes , P , Clarke , T K , Craddock , N , Cruceanu , C , Curtis , D , de Geus , E J C , Fischer , S B , Hottenga , J-J , Middeldorp , C M , Milaneschi , Y , Penninx , B W J H , Willemsen , G & Bipolar Disorders Working Group of the Psychiatric Genomics Consortium 2017 , ' Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia ' , Translational Psychiatry , vol. 7 , no. 6 , pp. e1155 . https://doi.org/10.1038/tp.2017.115 |
| Schlagwörter: |
Journal Article
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-27228427 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/0c3cae21-8f77-4a76-b99f-664475fb3298 |
