A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol

Recent genome-wide association (GWA) studies described 95 loci controlling serum lipid levels. These common variants explain ~25% of the heritability of the phenotypes. To date, no unbiased screen for gene-environment interactions for circulating lipids has been reported. We screened for variants that modify the relationship between known epidemiological risk factors and circulating lipid levels in a meta-analysis of genome-wide association (GWA) data from 18 population-based cohorts with European ancestry (maximum N = 32,225). We collected 8 further cohorts (N = 17,102) for replication, and r... Mehr ...

Verfasser:	Surakka, I. Isaacs, A. Karssen, L.C. Laurila, P.P.P. Middelberg, R.P.S. Tikkanen, E. Ried, J.S. Lamina, C. Mangino, M. Igl, W. Hottenga, J.J. Lagou, V. van der Harst, P. Mateo Leach, I. Esko, T. Kutalik, Z. Wainwright, N.W. Struchalin, M.V. Sarin, A.P. Kangas, A.J. Viikari, J.S. Perola, M. Rantanen, T. Petersen, A.K. Soininen, P. Johansson, Å. Soranzo, N. Heath, A.C. Papamarkou, T. Prokopenko, I. Tönjes, A. Kronenberg, F. Döring, A. Rivadeneira, F. Montgomery, GW Whitfield, J.B. Kähönen, M. Lehtimäki, T. Freimer, N.B. Willemsen, G. de Geus, E.J.C. Palotie, A. Sandhu, M.S. Waterworth, D. Metspalu, A. Stumvoll, M. Uitterlinden, A.G. Navis, G. Wijmenga, C. Wolffenbuttel, B.H.R. Taskinen, M.R. Ala-Korpela, M. Kaprio, J. Kyvik, K.O. Boomsma, D.I. Pedersen, N.L. Gyllensten, U. Wilson, J.F. Rudan, I. Campbell, H. Pramstaller, P.P. Spector, T.D. Witteman, J.C.M. Eriksson, J.G. Salomaa, V. Oostra, B.A. Raitakari, O.T. Wichmann, H.E. Gieger, C. Järvelin, M.J. Martin, N.G. Hofman, A. McCarthy, M.I. Peltonen, L. van Duijn, C.M. Aulchenko, Y.S. Ripatti, S.
Dokumenttyp:	Artikel
Erscheinungsdatum:	2011
Reihe/Periodikum:	Surakka , I , Isaacs , A , Karssen , L C , Laurila , P P P , Middelberg , R P S , Tikkanen , E , Ried , J S , Lamina , C , Mangino , M , Igl , W , Hottenga , J J , Lagou , V , van der Harst , P , Mateo Leach , I , Esko , T , Kutalik , Z , Wainwright , N W , Struchalin , M V , Sarin , A P , Kangas , A J , Viikari , J S , Perola , M , Rantanen , T , Petersen , A K , Soininen , P , Johansson , Å , Soranzo , N , Heath , A C , Papamarkou , T , Prokopenko , I , Tönjes , A , Kronenberg , F , Döring , A , Rivadeneira , F , Montgomery , GW , Whitfield , J B , Kähönen , M , Lehtimäki , T , Freimer , N B , Willemsen , G , de Geus , E J C , Palotie , A , Sandhu , M S , Waterworth , D , Metspalu , A , Stumvoll , M , Uitterlinden , A G , Navis , G , Wijmenga , C , Wolffenbuttel , B H R , Taskinen , M R , Ala-Korpela , M , Kaprio , J , Kyvik , K O , Boomsma , D I , Pedersen , N L , Gyllensten , U , Wilson , J F , Rudan , I , Campbell , H , Pramstaller , P P , Spector , T D , Witteman , J C M , Eriksson , J G , Salomaa , V , Oostra , B A , Raitakari , O T , Wichmann , H E , Gieger , C , Järvelin , M J , Martin , N G , Hofman , A , McCarthy , M I , Peltonen , L , van Duijn , C M , Aulchenko , Y S & Ripatti , S 2011 , ' A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol ' , PLoS Genetics , vol. 7 , no. 10 , e1002333 . https://doi.org/10.1371/journal.pgen.1002333
Schlagwörter:	/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache:	Englisch
Permalink:	https://search.fid-benelux.de/Record/base-27228349
Datenquelle:	BASE; Originalkatalog
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Link(s) :	https://research.vu.nl/en/publications/031878f7-353a-4f7d-a7c6-d61ff62f7d25