Effectiveness of fixed dose combination medication ('polypills') compared with usual care in patients with cardiovascular disease or at high risk: A prospective, individual patient data meta-analysis of 3140 patients in six countries
Aims To conduct a prospective, individual participant data (IPD) meta-analysis of randomised controlled trials comparing a polypill-based approach with usual care in high risk individuals. Methods and results Three trials comparing polypill-based care with usual care in individuals with CVD or high calculated cardiovascular risk contributed IPD. Primary outcomes were self-reported adherence to combination therapy (anti-platelet, statin and ≥ two blood pressure (BP) lowering agents), and difference in mean systolic BP (SBP) and LDL-cholesterol at 12 months. Analyses used random effects models.... Mehr ...
Verfasser: |
Webster, R
Patel, A
Selak, V
Billot, L
Bots, ML
Brown, A
Bullen, C
Cass, A
Crengle, S
Raina Elley, C
Grobbee, DE
Neal, B
Peiris, D
Poulter, N
Prabhakaran, D
Rafter, N
Stanton, A
Stepien, S
Thom, S
Usherwood, T
Wadham, A
Rodgers, A |
Dokumenttyp: |
journal article |
Erscheinungsdatum: |
2016 |
Verlag/Hrsg.: |
Elsevier
|
Schlagwörter: |
Prevention
/ Clinical Research
/ Clinical Trials and Supportive Activities
/ Heart Disease
/ Cardiovascular
/ Comparative Effectiveness Research
/ 6.1 Pharmaceuticals
/ 6 Evaluation of treatments and therapeutic interventions
/ Antihypertensive Agents
/ Australia
/ Cardiovascular Agents
/ Cardiovascular Diseases
/ Databases
/ Factual
/ Drug Combinations
/ England
/ Humans
/ Hydroxymethylglutaryl-CoA Reductase Inhibitors
/ India
/ Ireland
/ Netherlands
/ New Zealand
/ Platelet Aggregation Inhibitors
/ Prospective Studies
/ Randomized Controlled Trials as Topic
/ Risk Factors
/ Treatment Outcome
/ Cardiovascular disease
/ Meta-analysis
/ Polypill
/ Secondary prevention
/ SPACE Collaboration
/ anzsrc-for: 1102 Cardiorespiratory Medicine and Haematology
/ anzsrc-for: 1117 Public Health and Health Services |
Sprache: |
unknown |
Permalink: |
https://search.fid-benelux.de/Record/base-27224366 |
Datenquelle: |
BASE;
Originalkatalog |
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BASE |
Link(s) :
|
http://hdl.handle.net/1959.4/unsworks_76747 |