Hospice care aims to optimize the quality of life of patients with a life-limiting illness and their families. Hospices were initiated to ameliorate and de-medicalize care for the dying. Patients with a life expectancy of <3 months have access to hospice care, a large and heterogenic population. The differences in hospice care should fit the needs of patients admitted. The twofolded aim of this thesis was 1) to explore hospice care in the Netherlands and 2) to gain insight into hospice patients’ symptoms and well-being. Part I Exploration of hospice care in the Netherlands Exploration of hospice care resulted in six core characteristics of professional-driven hospices: 1) admittance of patients <3 months estimated life expectancy; 2) last resort, respite, crisis and day care; 3) multidimensional care; 4) professionals and trained volunteers. 5) home-like, respect and autonomy; 6) community services, education and research. The operationalization differs largely between hospices. Multidimensional care was not always identifiable in patient records, however its importance was underpinned by caregivers. Most attention was paid to the physical dimension; the social and spiritual dimensions were less described. Interdisciplinary collaboration, methods of clinical reasoning, and supportive structures promote multidimensional care. The hospice assist at home (HaHo) service, aims to enable patients to die at their preferred location. The preferred place of death was known for 122/130 patients, of whom 91% died at their preferred location. Part II Symptoms and well-being of hospice patients The influence of age on hospice patients’ symptom burden was relatively small. Pain had a significant higher prevalence and severity scores in patients <65 than in older patients. The prevalence of anorexia was highest for patients aged ≥85. At admission, fatigue, depressed mood, and anorexia explained 49% of the variance of well-being. During admission, fatigue, pain, anorexia, dyspnea, depressed mood, and anxiety were ...