Sequence analysis of the 5' untranslated region in isolates of at least four genotypes of hepatitis C virus in The Netherlands
The RNAs of hepatitis C virus (HCV) isolates from 62 patients with chronic HCV infection were analyzed by direct sequencing of the 5' untranslated region. Two important sequence motifs were recognized: one between positions -170 and -155 and the other between positions -132 and -117. These motifs are partly complementary. All three previously published genotypes were observed; 34 (55%) isolates were classified as type 1 (including prototype [from the United States] and HCV-BK [from Japan] sequences), 11 (18%) were classified as type 2 (including HC-J6 and HC-J8), and 12 (19%) were classified a... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 1994 |
Schlagwörter: | Adult / Aged / Base Sequence / DNA / Viral/genetics / Genotype / Hepacivirus/classification/*genetics/isolation & purification / Hepatitis C/genetics/*microbiology / Humans / Middle Aged / Molecular Sequence Data / Netherlands / Polymerase Chain Reaction / Sequence Homology / Nucleic Acid / Variation (Genetics) |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27218046 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://repub.eur.nl/pub/8590 |