A highly virulent variant of HIV-1 circulating in the Netherlands
We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log 10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of trans... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2022 |
Schlagwörter: | info:eu-repo/classification/ddc/616 / Adult / Anti-HIV Agents / therapeutic use / CD4 Lymphocyte Count / Evolution / Molecular / Female / Genome / Viral / Genotype / HIV Infections / drug therapy / HIV Infections / immunology / HIV Infections / transmission / HIV Infections / virology / HIV-1 / genetics / HIV-1 / pathogenicity / HIV-1 / physiology / Humans / Male / Mutation / Netherlands / Phylogeny / Viral Load / Virulence |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27215198 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://archive-ouverte.unige.ch/unige:166608 |