Preface. In follow-up to the four previous conferences, which were held in Utrecht, Groningen, Tilburg and Ravenstein, the fifth edition of the SIKS/BENAIS Conference on Enterprise Information Systems (EIS 2010) is held in Eindhoven this year. The purpose of the conference series is to bring together Dutch and Belgian researchers interested in the advances in and the business applications of information systems. Against that backdrop, we are happy to have received contributions from almost all of the Dutch and Belgian research groups active in this field. Overall, the program consists of 16 presentations of which six concern totally new work. Each of these was duly reviewed by at least three members of the program committee. The remaining 10 presentations relate to work already being published in a high-quality outlet and considered highly attractive to bring under the attention of the Dutch/Belgian EIS community. On top of these presentations, we are very happy with the incorporation of two keynote presentations in the program. The opening keynote is to be given by Theodoor van Donge, CTO at Cordys and responsible for R&D. The closing keynote will be provided by prof. John Krogstie from the Norwegian University of Science and Technology. At this occasion, we wish to express first and foremost our gratitude to the members of the EIS community who have fulfilled roles in the program committee for this conference. Their valuable feedback has helped the presenters to further improve their work. We also wish to thank SIKS, BENAIS, NIRICT, LOIS, and all involved local staff at Eindhoven University of Technology for their support in organizing this event. It is our hope that the conference will stimulate discussions in our community, foster existing collaborations and lead to new ones. But most important of all, we hope that you will enjoy the conference day.