Widespread Detection of Yersiniabactin Gene Cluster and Its Encoding Integrative Conjugative Elements (ICEKp) among Nonoutbreak OXA-48-Producing Klebsiella pneumoniae Clinical Isolates from Spain and the Netherlands

In this study, we determined the presence of virulence factors in nonoutbreak, high-risk clones and other isolates belonging to less common sequence types associated with the spread of OXA-48-producing Klebsiella pneumoniae clinical isolates from The Netherlands (n = 61) and Spain (n = 53). Most isolates shared a chromosomally encoded core of virulence factors, including the enterobactin gene cluster, fimbrial fim and mrk gene clusters, and urea metabolism genes (ureAD). We observed a high diversity of K-Locus and K/O loci combinations, KL17 and KL24 (both 16%), and the O1/O2v1 locus (51%) bei... Mehr ...

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Dokumenttyp: Artikel
Erscheinungsdatum: 2023
Reihe/Periodikum: Dutch and Spanish Collaborative Working Groups on Surveillance on Carbapenemase-Producing Enterobacterales 2023 , ' Widespread Detection of Yersiniabactin Gene Cluster and Its Encoding Integrative Conjugative Elements (ICEKp) among Nonoutbreak OXA-48-Producing Klebsiella pneumoniae Clinical Isolates from Spain and the Netherlands ' , Microbiology Spectrum , vol. 11 , no. 4 , e0471622 . https://doi.org/10.1128/spectrum.04716-22
Schlagwörter: Humans / Klebsiella pneumoniae / beta-Lactamases/genetics / Klebsiella Infections/epidemiology / Spain/epidemiology / Netherlands / Virulence Factors/genetics / Multigene Family / Anti-Bacterial Agents / Bacterial Proteins/genetics
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-27211419
Datenquelle: BASE; Originalkatalog
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Link(s) : https://hdl.handle.net/11370/d848ee3b-f515-477e-93a6-3dae9ec43c0c