Healthy Cotwins Share Gut Microbiome Signatures With Their Inflammatory Bowel Disease Twins and Unrelated Patients
BACKGROUND & AIMS: It is currently unclear whether reported changes in the gut microbiome are cause or consequence of inflammatory bowel disease (IBD). Therefore, we studied the gut microbiome of IBD-discordant and -concordant twin pairs, which offers the unique opportunity to assess individuals at increased risk of developing IBD, namely healthy cotwins from IBD-discordant twin pairs. METHODS: Fecal samples were obtained from 99 twins (belonging to 51 twin pairs), 495 healthy age-, sex- and BMI-matched controls, and 99 unrelated IBD patients. Whole-genome metagenomic shotgun sequencing wa... Mehr ...
Verfasser: |
Brand, Eelco C
Klaassen, Marjolein A Y
Gacesa, Ranko
Vila, Arnau Vich
Ghosh, Hiren
de Zoete, Marcel R
Boomsma, Dorret I
Hoentjen, Frank
Horjus Talabur Horje, Carmen S
van de Meeberg, Paul C
Willemsen, Gonneke
Fu, Jingyuan
Wijmenga, Cisca
van Wijk, Femke
Zhernakova, Alexandra
Oldenburg, Bas
Weersma, Rinse K |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2021 |
Reihe/Periodikum: |
Brand , E C , Klaassen , M A Y , Gacesa , R , Vila , A V , Ghosh , H , de Zoete , M R , Boomsma , D I , Hoentjen , F , Horjus Talabur Horje , C S , van de Meeberg , P C , Willemsen , G , Fu , J , Wijmenga , C , van Wijk , F , Zhernakova , A , Oldenburg , B , Weersma , R K & Dutch TWIN-IBD consortium and the Dutch Initiative on Crohn and Colitis 2021 , ' Healthy Cotwins Share Gut Microbiome Signatures With Their Inflammatory Bowel Disease Twins and Unrelated Patients ' , Gastroenterology , vol. 160 , no. 6 , pp. 1970-1985 . https://doi.org/10.1053/j.gastro.2021.01.030 |
Schlagwörter: |
Preclinical
/ Prediagnostic
/ Crohn's Disease
/ Ulcerative Colitis
/ Family Studies
/ Microbiota
/ Prediction
/ Discordant Twin Design
/ GENETICS
/ METAGENOMICS
/ NETHERLANDS
/ POLYAMINES
/ REMISSION
/ MUCOSA
/ INDEX |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27211226 |
Datenquelle: |
BASE;
Originalkatalog |
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BASE |
Link(s) :
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https://hdl.handle.net/11370/c45a527e-a5cf-4111-bb6c-515882dc22df |