Bridging the gap between the randomised clinical trial world and the real world by combination of population-based registry and electronic health record data:A case study in haemato-oncology

Randomised clinical trials (RCTs) are considered the basis of evidence-based medicine. It is recognised more and more that application of RCT results in daily practice of clinical decision-making is limited because the RCT world does not correspond with the clinical real world. Recent strategies aiming at substitution of RCT databases by improved population-based registries (PBRs) or by improved electronic health record (EHR) systems to provide significant data for clinical science are discussed. A novel approach exemplified by the HemoBase haemato-oncology project is presented. In this approa... Mehr ...

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Verfasser: Kibbelaar, R E
Oortgiesen, B E
van der Wal-Oost, A M
Boslooper, K
Coebergh, J W
Veeger, N J G M
Joosten, P
Storm, H
van Roon, E N
Hoogendoorn, M
Dokumenttyp: Artikel
Erscheinungsdatum: 2017
Reihe/Periodikum: Kibbelaar , R E , Oortgiesen , B E , van der Wal-Oost , A M , Boslooper , K , Coebergh , J W , Veeger , N J G M , Joosten , P , Storm , H , van Roon , E N & Hoogendoorn , M 2017 , ' Bridging the gap between the randomised clinical trial world and the real world by combination of population-based registry and electronic health record data : A case study in haemato-oncology ' , European Journal of Cancer , vol. 86 , pp. 178-185 . https://doi.org/10.1016/j.ejca.2017.09.007
Schlagwörter: Electronic health record / Population-based registry / Randomised clinical trial / Evidence-based medicine / Haematology / Oncology / B-CELL LYMPHOMA / NETHERLANDS CANCER REGISTRY / MULTIPLE-MYELOMA PATIENTS / HEMATOLOGICAL MALIGNANCIES / PHAROS-REGISTRY / INFERENTIAL GAP / PUBLIC-HEALTH / SURVIVAL / EUROPE / DISEASE
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-27209431
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://hdl.handle.net/11370/29772a8d-1671-4917-ad8a-90b009e84acc

Randomised clinical trials (RCTs) are considered the basis of evidence-based medicine. It is recognised more and more that application of RCT results in daily practice of clinical decision-making is limited because the RCT world does not correspond with the clinical real world. Recent strategies aiming at substitution of RCT databases by improved population-based registries (PBRs) or by improved electronic health record (EHR) systems to provide significant data for clinical science are discussed. A novel approach exemplified by the HemoBase haemato-oncology project is presented. In this approach, a PBR is combined with an advanced EHR, providing high-quality data for observational studies and support of best practice development. This PBR + EHR approach opens a perspective on randomised registry trials.