Longitudinal Characterization of the Mumps-Specific HLA-A2 Restricted T-Cell Response after Mumps Virus Infection
Waning of the mumps virus (MuV)-specific humoral response after vaccination has been suggested as a cause for recent mumps outbreaks in vaccinated young adults, although it cannot explain all cases. Moreover, CD8(+) T cells may play an important role in the response against MuV; however, little is known about the characteristics and dynamics of the MuV-specific CD8(+) T-cell response after MuV infection. Here, we had the opportunity to follow the CD8(+) T-cell response to three recently identified HLA-A2*02:01-restricted MuV-specific epitopes from 1.5 to 36 months post-MuV infection in five pr... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2021 |
Reihe/Periodikum: | Lanfermeijer , J , Nuehn , M M , Emmelot , M E , Poelen , M C M , van Els , C A C M , Borghans , J A M , van Baarle , D , Kaaijk , P & de Wit , J 2021 , ' Longitudinal Characterization of the Mumps-Specific HLA-A2 Restricted T-Cell Response after Mumps Virus Infection ' , Vaccines , vol. 9 , no. 12 , 1431 . https://doi.org/10.3390/vaccines9121431 ; ISSN:2076-393X |
Schlagwörter: | mumps infection / T-cell immunity / MMR vaccination / BONE-MARROW / MEMORY / DYNAMICS / IMMUNITY / VACCINE / DIFFERENTIATION / PROLIFERATION / NETHERLANDS / OUTBREAKS / MEASLES |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27209130 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://hdl.handle.net/11370/0a0cecd4-1e3e-4f5a-86f0-521ff35de5f9 |
Waning of the mumps virus (MuV)-specific humoral response after vaccination has been suggested as a cause for recent mumps outbreaks in vaccinated young adults, although it cannot explain all cases. Moreover, CD8(+) T cells may play an important role in the response against MuV; however, little is known about the characteristics and dynamics of the MuV-specific CD8(+) T-cell response after MuV infection. Here, we had the opportunity to follow the CD8(+) T-cell response to three recently identified HLA-A2*02:01-restricted MuV-specific epitopes from 1.5 to 36 months post-MuV infection in five previously vaccinated and three unvaccinated individuals. The infection-induced CD8(+) T-cell response was dominated by T cells specific for the ALDQTDIRV and LLDSSTTRV epitopes, while the response to the GLMEGQIVSV epitope was subdominant. MuV-specific CD8(+) T-cell frequencies in the blood declined between 1.5 and 9 months after infection. This decline was not explained by changes in the expression of inhibitory receptors or homing markers. Despite the ongoing changes in the frequencies and phenotype of MuV-specific CD8(+) T cells, TCR beta analyses revealed a stable MuV-specific T-cell repertoire over time. These insights in the maintenance of the cellular response against mumps may provide hallmarks for optimizing vaccination strategies towards a long-term cellular memory response.