Within the broad context of EU Decision 1082/2013/EU on serious cross-border threats to health, the European Centre for Disease Prevention and Control (ECDC) has initiated a case study project to investigate the synergies between communities affected by serious public health threats and the institutions (both health- and non-healthrelated) mandated to prepare for and respond to them. The premise for the project is that affected communities are increasingly recognised as key resources that can be used during public health emergencies, and that the concerns and experience of ordinary people should be harnessed as an important part of the response. The aim of this qualitative comparative case study project is to identify good practices related to community preparedness for tick-borne diseases. Two EU countries, Spain and the Netherlands, were selected for inclusion. Work in Spain focused around two cases of autochthonous infection with Crimean-Congo haemorrhagic fever (CCHF) virus that emerged in the Autonomous Community of Castilla y León in August 2016. Work in the Netherlands focussed on the first two endemic cases of tick-borne encephalitis (TBE) in the country, appearing in July 2016 in the Utrecht and Twente regions. The response to the TBE cases was undertaken within the wider context of prevention work on lyme borreliosis (LB) in the country. Specifically, the study aims to: - Identify good practices and patterns of cooperation between affected communities and the official institutions mandated to address tick-borne diseases; - Identify inter-sectoral collaboration between health and non-health-related sectors with regard to tick-borne diseases; - Identify practices that could be of use for other EU countries in the area of public health preparedness.