Preferences of people living with HIV for injectable and oral antiretroviral treatment in the Netherlands:a discrete choice experiment
Injectable antiretroviral treatment (ART) represents a new effective and potentially more convenient alternative to oral ART for people living with HIV (PLWH). This study assessed preferences of PLWH for long-acting injectable compared with oral ART in the Netherlands. A labelled discrete choice experiment presented 12 choice sets of long-acting injectable and oral ART. PLWH were asked to select their preferred ART, described by six attributes: location of administration, dosing frequency, risk of short-term side effects, drug-drug interaction, forgivability, and food and mealtime restrictions... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2024 |
Reihe/Periodikum: | Kremer , I E H , Beaudart , C , Simons , J , Plieger , H , Schroeder , M & Hiligsmann , M 2024 , ' Preferences of people living with HIV for injectable and oral antiretroviral treatment in the Netherlands : a discrete choice experiment ' , Aids Care-Psychological and Socio-Medical Aspects of Aids/Hiv , vol. 36 , no. 4 , pp. 536-545 . https://doi.org/10.1080/09540121.2023.2240067 |
Schlagwörter: | Antiretroviral therapy / discrete choice experiment / long-acting injectable / oral therapy / people living with HIV / preferences / > / HEALTH |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27206828 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://cris.maastrichtuniversity.nl/en/publications/c6936189-ed57-43fa-9f63-972cf7d41806 |
Injectable antiretroviral treatment (ART) represents a new effective and potentially more convenient alternative to oral ART for people living with HIV (PLWH). This study assessed preferences of PLWH for long-acting injectable compared with oral ART in the Netherlands. A labelled discrete choice experiment presented 12 choice sets of long-acting injectable and oral ART. PLWH were asked to select their preferred ART, described by six attributes: location of administration, dosing frequency, risk of short-term side effects, drug-drug interaction, forgivability, and food and mealtime restrictions. Random parameters logit and latent class models were used to estimate preferences of PLWH. 98.6% of 76 respondents were experienced oral ART users that had taken ART for a median of 12 years (Q1-Q3: 7.0-20.0). 30 (39.5%) respondents chose long-acting injectable ART in all choice tasks and 22 (28.9%) always chose oral ART. The random parameter model showed that, on average, respondents significantly favoured long-acting injectable ART over oral ART, preferred administration of the long-acting injectable ART at home, and a less frequent regimen. The latent class model confirmed one class strongly preferring long-acting injectable ART and one class slightly preferring oral ART. This study highlights the value for both long-acting injectable and oral ART.