Designing and Testing of a Health-Economic Markov Model for Prevention and Treatment of Early Psychosis

BACKGROUND: This study aims to report on the design of a model to determine the cost-effectiveness of prevention and treatment of early psychosis (PsyMod) and to estimate ten-year cost-effectiveness and budget impact of interventions targeting individuals with ultra-high risk (UHR) of developing psychosis or with first episode psychosis (FEP). METHODS: PsyMod was built in parallel with the development of a new standard of care for treatment of early psychosis in the Netherlands. PsyMod is a state-transition cohort simulation model and considers six health states, namely ultra-high risk of psyc... Mehr ...

Volltext
Verfasser: Wijnen, Ben F M
Thielen, Frederick W
Konings, Steef
Feenstra, Talitha
Van Der Gaag, Mark
Veling, Wim
De Haan, Lieuwe
Ising, Helga
Hiligsmann, Mickaël
Evers, Silvia M A A
Smit, Filip
Lokkerbol, Joran
Dokumenttyp: Artikel
Erscheinungsdatum: 2020
Reihe/Periodikum: Wijnen , B F M , Thielen , F W , Konings , S , Feenstra , T , Van Der Gaag , M , Veling , W , De Haan , L , Ising , H , Hiligsmann , M , Evers , S M A A , Smit , F & Lokkerbol , J 2020 , ' Designing and Testing of a Health-Economic Markov Model for Prevention and Treatment of Early Psychosis ' , Expert Review of Pharmacoeconomics & Outcomes Research , vol. 20 , no. 3 , pp. 269-279 . https://doi.org/10.1080/14737167.2019.1632194
Schlagwörter: Budgets / Cognitive Behavioral Therapy/economics / Cohort Studies / Computer Simulation / Cost-Benefit Analysis / Health Care Costs/statistics & numerical data / Humans / Markov Chains / Models / Economic / Netherlands / Psychotic Disorders/economics / Quality-Adjusted Life Years / Risk / COST-EFFECTIVENESS ANALYSIS / EARLY INTERVENTION / ULTRA-HIGH-RISK / Schizophrenia / FOLLOW-UP / RISPERIDONE / psychosis / health economic modelling / ANTIPSYCHOTICS / 1ST-EPISODE PSYCHOSIS / 1ST EPISODE / cost-effectiveness / budget impact / UNTREATED PSYCHOSIS / economic evaluation
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-27205665
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://cris.maastrichtuniversity.nl/en/publications/00407f2d-82d9-4db1-8fbd-bf1406db959b

BACKGROUND: This study aims to report on the design of a model to determine the cost-effectiveness of prevention and treatment of early psychosis (PsyMod) and to estimate ten-year cost-effectiveness and budget impact of interventions targeting individuals with ultra-high risk (UHR) of developing psychosis or with first episode psychosis (FEP). METHODS: PsyMod was built in parallel with the development of a new standard of care for treatment of early psychosis in the Netherlands. PsyMod is a state-transition cohort simulation model and considers six health states, namely ultra-high risk of psychosis (UHR), FEP, post-FEP, no-UHR, recovery/remission, and death. Results are expressed as total healthcare costs, QALYs, incremental cost-effectiveness ratio (ICER), and budget impact. RESULTS: PsyMod was used to extrapolate budget impact and cost-effectiveness of cognitive behavioural therapy for preventing FEP for individuals at UHR of psychosis (CBTuhr) compared to care as usual. CBTuhr resulted in a per-patient increase of 0.06 QALYs and a per patient cost reduction of €654 (dominant ICER) with a reduction in 5-year healthcare costs of €1,002,166. CONCLUSIONS: PsyMod can be used to examine cost-effectiveness and budget impact of interventions targeting prevention and treatment of FEP and is freely available for academic purposes upon request by the authors.