Muscle relaxants allergy.

The most common agents that are responsible for intraoperative anaphylaxis are muscle relaxants. In fact, neuromuscular blocking agents (NMBAs) contribute to 50–70% of allergic reactions during anaesthesia. The main mechanism of hypersensitivity reactions to NMBAs is represented by acute type I allergic reactions and the most severe form is anaphylaxis. The rate of non IgE mediated immediate hypersensitivity reactions usually varies between 20 % and 35% of the reported cases in most large series. In a recent report, non allergic suspected reactions to NMBAs occurred with almost the same freque... Mehr ...