In the last years, the importance of balancing urban and rural development and the conservation of Nature has become crucial worldwide, and this is a challenge for Governments around the world; the rapid urbanisation, the development of the industrial sector and others have damaged the environment, e.g. climate change tremendously. The necessity to improve or change the current measures is essential to meet the high demand and, at the same time, decrease the impact on the environment, win-win solutions. Nature-Based Solutions (NBS) are inspired and supported by Nature, cost-effective, and simultaneously giving environmental, social and economic benefits; one of the most important aims of these measures is reducing flood risk, which is increasingly concerning countries worldwide. As a result, the successful implementation of these measures requires extensive coordination in multi-level governance, robust planning, and a multifunctional approach. Room for the River project is an excellent example of how a large-scale project can be successfully implemented, with two main objectives: flood protection and spatial quality improvement. This project is well-known worldwide for achieving both aims on time, transforming it as the most extensive water construction since the Delta works. This research is focused on the potential replicability of the Room for the river programme in the Serbian case study, considering the barriers faced during each phase of the project, the benefits, which NBS measures can be implemented, the influence of the NBS project on public policies, and how to construct a business model to ensure financing of the project.