Invasive Group A Streptococcal Disease in The Netherlands: Evidence for a Protective Role of Anti-Exotoxin A Antibodies
As part of a nationwide surveillance in The Netherlands during 1994–1997, 53 patients with invasive group A streptococcal (GAS) infections were evaluated for medical history, symptoms, and outcome. Patients' isolates were tested for the production of pyrogenic exotoxins A (SPE-A) and B (SPE-B). Acute-phase sera from all patients and convalescent sera from 12 patients were investigated for the presence of antibodies against SPE-A and SPE-B. Twenty-three patients developed toxic shock-like syndrome and 16 died. Absence of antibodies against SPE-A and/or SPE-B was a risk factor for developing inv... Mehr ...
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Dokumenttyp: | TEXT |
Erscheinungsdatum: | 2000 |
Verlag/Hrsg.: |
Oxford University Press
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Schlagwörter: | Major Articles |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27196226 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://jid.oxfordjournals.org/cgi/content/short/181/2/631 |
As part of a nationwide surveillance in The Netherlands during 1994–1997, 53 patients with invasive group A streptococcal (GAS) infections were evaluated for medical history, symptoms, and outcome. Patients' isolates were tested for the production of pyrogenic exotoxins A (SPE-A) and B (SPE-B). Acute-phase sera from all patients and convalescent sera from 12 patients were investigated for the presence of antibodies against SPE-A and SPE-B. Twenty-three patients developed toxic shock-like syndrome and 16 died. Absence of antibodies against SPE-A and/or SPE-B was a risk factor for developing invasive streptococcal disease. Toxic shock and mortality were associated with a lack of anti-SPE-A antibodies ( P < .025). Anti-SPE-A antibodies were found in convalescent sera from all patients infected by speA- positive isolates. Virtually all invasive speA -positive streptococci expressed SPE-A protein in vitro. Thus antibodies against SPE-A appeared vital for mediating the outcome of invasive GAS disease in this population.