Immunogenicity in Rabbits of Virus-Like Particles from a Contemporary Rabbit Haemorrhagic Disease Virus Type 2 (GI.2/RHDV2/b) Isolated in The Netherlands
Rabbit haemorrhagic disease virus (RHDV) type 2 (GI.2/RHDV2/b) is an emerging pathogen in wild rabbits and in domestic rabbits vaccinated against RHDV (GI.1). Here we report the genome sequence of a contemporary RHDV2 isolate from the Netherlands and investigate the immunogenicity of virus-like particles (VLPs) produced in insect cells. RHDV2 RNA was isolated from the liver of a naturally infected wild rabbit and the complete viral genome sequence was assembled from sequenced RT-PCR products. Phylogenetic analysis based on the VP60 capsid gene demonstrated that the RHDV2 NL2016 isolate cluster... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2019 |
Reihe/Periodikum: | Viruses, Vol 11, Iss 6, p 553 (2019) |
Verlag/Hrsg.: |
MDPI AG
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Schlagwörter: | rabbit haemorrhagic disease virus 2 (GI.2/RHDV2/b) / Netherlands / VP60 / baculovirus expression / virus-like particles / insect cells / immunogenicity / Microbiology / QR1-502 |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27192925 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://doi.org/10.3390/v11060553 |