Mycobacterium canettii, the Smooth Variant of M. tuberculosis, Isolated from a Swiss Patient Exposed in Africa
An exceptionally smooth and glossy morphotype of Mycobacterium tuberculosis complex was isolated from a 56-year-old Swiss patient with mesenteric tuberculosis. Direct 16S rRNA sequence analysis of the hypervariable signature gene regions revealed a 100% homology to the specific M. tuberculosis complex sequence. Spoligotyping and restriction fragment length polymorphism analyses using the insertion sequences IS6110 and IS1081 and the polymorphic GC-rich sequence as additional genetic markers identified the isolate as the novel taxon M. canettii. Like a Somali child with a similar case, this pat... Mehr ...
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| Dokumenttyp: | Artikel |
| Erscheinungsdatum: | 1998 |
| Reihe/Periodikum: | Emerging Infectious Diseases, Vol 4, Iss 4, Pp 631-634 (1998) |
| Verlag/Hrsg.: |
Centers for Disease Control and Prevention
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| Schlagwörter: | Kenya / Switzerland / the Netherlands / Medicine / R / Infectious and parasitic diseases / RC109-216 |
| Sprache: | Englisch |
| Permalink: | https://search.fid-benelux.de/Record/base-27191630 |
| Datenquelle: | BASE; Originalkatalog |
| Powered By: | BASE |
| Link(s) : | https://doi.org/10.3201/eid0404.980414 |
An exceptionally smooth and glossy morphotype of Mycobacterium tuberculosis complex was isolated from a 56-year-old Swiss patient with mesenteric tuberculosis. Direct 16S rRNA sequence analysis of the hypervariable signature gene regions revealed a 100% homology to the specific M. tuberculosis complex sequence. Spoligotyping and restriction fragment length polymorphism analyses using the insertion sequences IS6110 and IS1081 and the polymorphic GC-rich sequence as additional genetic markers identified the isolate as the novel taxon M. canettii. Like a Somali child with a similar case, this patient probably contracted the infection in Africa, which raises questions about the geographic distribution of M. canettii.