Cardiovascular Risk Associated with Interactions among Polymorphisms in Genes from the Renin-Angiotensin, Bradykinin, and Fibrinolytic Systems
Background: Vascular fibrinolytic balance is maintained primarily by interplay of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1). Previous research has shown that polymorphisms in genes from the renin- angiotensin (RA), bradykinin, and fibrinolytic systems affect plasma concentrations of both t-PA and PAI-1 through a set of gene-gene interactions. In the present study, we extend this finding by exploring the effects of polymorphisms in genes from these systems on incident cardiovascular disease, explicitly examining two-way interactions in a large popula... Mehr ...
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Dokumenttyp: | Text |
Erscheinungsdatum: | 2010 |
Verlag/Hrsg.: |
Dartmouth Digital Commons
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Schlagwörter: | adult / aged / bradykinin / cardiovascular diseases / european continental ancestry group / female / follow-up studies / genetic predisposition to disease / humans / male / middle aged / netherlands / polymorphism / genetic / renin-angiotensin system / risk factors / tissue plasminogen activator / Medicine and Health Sciences |
Sprache: | unknown |
Permalink: | https://search.fid-benelux.de/Record/base-27181554 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://digitalcommons.dartmouth.edu/facoa/2580 |