Lifetime prevalence, age of risk, and genetic relationships of comorbid psychiatric disorders in Tourette syndrome.

ImportanceTourette syndrome (TS) is characterized by high rates of psychiatric comorbidity; however, few studies have fully characterized these comorbidities. Furthermore, most studies have included relatively few participants (<200), and none has examined the ages of highest risk for each TS-associated comorbidity or their etiologic relationship to TS.ObjectiveTo characterize the lifetime prevalence, clinical associations, ages of highest risk, and etiology of psychiatric comorbidity among individuals with TS.Design, setting, and participantsCross-sectional structured diagnostic interviews... Mehr ...

Verfasser: Hirschtritt, Matthew E
Lee, Paul C
Pauls, David L
Dion, Yves
Grados, Marco A
Illmann, Cornelia
King, Robert A
Sandor, Paul
McMahon, William M
Lyon, Gholson J
Cath, Danielle C
Kurlan, Roger
Robertson, Mary M
Osiecki, Lisa
Scharf, Jeremiah M
Mathews, Carol A
Tourette Syndrome Association International Consortium for Genetics
Dokumenttyp: Artikel
Erscheinungsdatum: 2015
Reihe/Periodikum: JAMA psychiatry, vol 72, iss 4
Verlag/Hrsg.: eScholarship
University of California
Schlagwörter: Tourette Syndrome Association International Consortium for Genetics / Humans / Tourette Syndrome / Prevalence / Risk Factors / Mental Disorders / Age Factors / Age of Onset / Comorbidity / Age Distribution / Adolescent / Child / Preschool / Canada / United States / Netherlands / Female / Male / Young Adult / United Kingdom / Brain Disorders / Neurodegenerative / Clinical Research / Anxiety Disorders / Behavioral and Social Science / Serious Mental Illness / Genetics / Attention Deficit Hyperactivity Disorder (ADHD) / Pediatric / Neurosciences / Prevention / Mental Health / Aetiology / 2.3 Psychological / social and economic factors / Other Medical and Health Sciences / Psychology / Cognitive Sciences
Sprache: unknown
Permalink: https://search.fid-benelux.de/Record/base-27180680
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://escholarship.org/uc/item/1nn846ss

ImportanceTourette syndrome (TS) is characterized by high rates of psychiatric comorbidity; however, few studies have fully characterized these comorbidities. Furthermore, most studies have included relatively few participants (<200), and none has examined the ages of highest risk for each TS-associated comorbidity or their etiologic relationship to TS.ObjectiveTo characterize the lifetime prevalence, clinical associations, ages of highest risk, and etiology of psychiatric comorbidity among individuals with TS.Design, setting, and participantsCross-sectional structured diagnostic interviews conducted between April 1, 1992, and December 31, 2008, of participants with TS (n = 1374) and TS-unaffected family members (n = 1142).Main outcomes and measuresLifetime prevalence of comorbid DSM-IV-TR disorders, their heritabilities, ages of maximal risk, and associations with symptom severity, age at onset, and parental psychiatric history.ResultsThe lifetime prevalence of any psychiatric comorbidity among individuals with TS was 85.7%; 57.7% of the population had 2 or more psychiatric disorders. The mean (SD) number of lifetime comorbid diagnoses was 2.1 (1.6); the mean number was 0.9 (1.3) when obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) were excluded, and 72.1% of the individuals met the criteria for OCD or ADHD. Other disorders, including mood, anxiety, and disruptive behavior, each occurred in approximately 30% of the participants. The age of greatest risk for the onset of most comorbid psychiatric disorders was between 4 and 10 years, with the exception of eating and substance use disorders, which began in adolescence (interquartile range, 15-19 years for both). Tourette syndrome was associated with increased risk of anxiety (odds ratio [OR], 1.4; 95% CI, 1.0-1.9; P = .04) and decreased risk of substance use disorders (OR, 0.6; 95% CI, 0.3-0.9; P = .02) independent from comorbid OCD and ADHD; however, high rates of mood disorders among participants with TS (29.8%) may be ...