peer reviewed ; Over the 2003-2009 period, field campaigns were carried out in order to identify the main fungal diseases of winter wheat (Triticum aestivum) in the Grand-Duchy of Luxembourg. Four fungal diseases (septoria leaf blotch (SLB), wheat leaf rust (WLR), wheat powdery mildew (WPM) and fusarium head blight (FHB)) were observed and a regional-based typology was established according to their severity and prevalence. In the Gutland (South), SLB severity was strong (about 51% on average) and higher than the severity (about 16%) prevailing in the Oesling (North). Similar typology was observed with the WLR: high severity in the Gutland (66% and 57% for the years 2003 and 2007, respectively) and low severity (< 1%) in the Oesling. The FHB was also present in the Eastern part of the Gutland, with a prevalence and severity significantly higher (P = 0.049 and P = 0.012, respectively, Tukey’s test) compared with their values in the Oesling. On the other hand, the WPM severity was high in the Oesling (15% to 40%) while less than 1% in the Gutland. Such a study is important for the spatial mapping of wheat fungal diseases risk based on agroclimatic parameters and for defining optimal frequencies and dates of chemical treatments. ; Sentinelle