Molecular biological illustration of the idea of evolutionary search with BioRS.

(A) General idea of the battery of (identical) modules as it is formulated by Babiskin & Smolke [ 82 ]. (B) Our scheme of sequential search from scratch of a tetrameric aptamer. (C) Search scheme for a classic RS function with 4 BBs (above). Domains (BBs) separated by insulating spacers of predetermined length are searched sequentially from left to right. Delta is an increment of fitness level for each correctly found aptamer (BB). See text and legend to Fig 2 for the detailed description of an aptamer structure.

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Verfasser: Alexander V. Spirov (11302085)
Ekaterina M. Myasnikova (12008895)
Dokumenttyp: Image
Erscheinungsdatum: 2022
Schlagwörter: Biochemistry / Biotechnology / Evolutionary Biology / Infectious Diseases / Biological Sciences not elsewhere classified / larger building blocks / identifying short schemata / holland &# 8217 / dna -) rna / classical selectionist schemes / biological royal staircase / numerical tests showed / achieve significant savings / functional biological macromolecules / ec extensively study / already found modules / experimental evolutionary search / simple heuristic algorithms / many new algorithms / effective evolutionary search / vitro evolution approaches / biological macromolecules / evolutionary search / new algorithms / heuristic algorithms / significant increase / numerical analysis / evolutionary computation / vitro evolution / vitro </ / search recombine / genetic algorithms / synthetic biology / strong arguments / specific version / seems reasonable / schema theorem / quite suitable / publication arises / originally based / modular organization / key instrument / high fitness / functions ) / essentially accelerating / especially true / effectively applied / ec approaches / directed evolution / computer sciences
Sprache: unknown
Permalink: https://search.fid-benelux.de/Record/base-27106667
Datenquelle: BASE; Originalkatalog
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Link(s) : https://doi.org/10.1371/journal.pone.0260497.g003