Desphospho-uncarboxylated matrix Gla protein is a novel circulating biomarker predicting deterioration of renal function in the general population

Background. Recent studies showing an inverse association between estimated glomerular filtration rate (eGFR), a microvascular trait, and inactive desphospho-uncarboxylated matrix Gla protein (dp-ucMGP) support the hypothesis that after vitamin K-dependent activation, matrix Gla protein (MGP) is renoprotective, but these were limited by their cross-sectional design. Methods. In 1009 randomly recruited Flemish (50.6% women), we assessed the association between eGFR and plasma dpucMGP, usingmultivariable-adjusted analyses. Results. From baseline to follow-up 8.9 years later (median), dp-ucMGP in... Mehr ...