The crustal structure of the NE Flemish Cap margin was determined along a 460-km-long refraction/wide-angle reflection seismic transect (FLAME Line) to define the thickness, structure and composition of the crust and uppermost mantle along the line. A P -wave velocity model was developed from forward and inverse modelling of dense airgun shots recorded by 19 ocean bottom seismometers. A coincident multichannel seismic profile was used to guide the modelling as reflections could be identified down to Moho. The model displays a sediment cover of up to 3.6-km-thick, subdivided into three layers with velocities of 1.8–1.9 km s−1, 2.8–3.1 km s−1 and 4.7–4.8 km s−1. For the western part of the FLAME Line over Flemish Cap, the P -wave velocity model displays an up to 32-km-thick, three-layer continental crust. The continental crust has velocities of 5.8–6.1 km s−1, 6.3–6.45 km s−1 and 6.65–6.85 km s−1 and thicknesses of about 5 km, 7 km and 20 km in the upper, middle and lower layers, respectively. The thick continental crust thins to a two-layer, 6-km-thick crust (upper layer is 5.55–6.0 km s−1 and the layer below is 6.65–6.8 km s−1) over a distance of 45 km. S -wave velocities are determined in the upper layer of the thick continental crust over Flemish Cap and the transition zone by assigning Poisson's ratios in the P -wave velocity model. Comparison of calculated to observed arrival times gives a Poisson's ratio of 0.27 in the upper layer and 0.28 in the layer below, which suggests that the composition of the crust is primarily continental in both the thick crust and the thin crust of the transition zone. The thin continental crust is stretched over a width of 80 km and is underlain by a layer with velocities of 7.5–7.9 km s−1. We interpret this layer as partially serpentinized mantle, which is consistent with observations from the Newfoundland margin to the south. The serpentinized mantle terminates 30 km seaward of the thick continental crust. At the seaward-most end of the thin continental crust, a prominent ...