Virological responses to lamivudine or emtricitabine when combined with tenofovir and a protease inhibitor in treatment‐naïve HIV‐1‐infected patients in the Dutch AIDS Therapy Evaluation in the Netherlands ( ATHENA) cohort

Objectives Lamivudine (3 TC ) and emtricitabine ( FTC ) are considered interchangeable in recommended tenofovir disoproxil‐fumarate ( TDF )‐containing combination antiretroviral therapies ( cART s). This statement of equivalence has not been systematically studied. We compared the treatment responses to 3 TC and FTC combined with TDF in boosted protease inhibitor ( PI )‐based cART for HIV ‐1‐infected patients. Methods An observational study in the AIDS Therapy Evaluation in the Netherlands ( ATHENA ) cohort was carried out between 2002 and 2013. Virological failure rates, time to HIV RNA suppr... Mehr ...