Prostate carcinoma detection and increased prostate‐specific antigen levels after 4 years in Dutch and Japanese males who had no evidence of disease at initial screening

Abstract BACKGROUND In the current study, the authors set out to investigate the possibility that increased prostate‐specific antigen (PSA) levels in Dutch and Japanese men without suspicious findings at initial prostate cancer screening were indicative of the risk of newly developing clinical malignancy in the Netherlands and Japan. METHODS Between 1992 and 2000, 2650 men ages 55–74 years who had PSA levels < 4.0 ng/mL and no suspicious findings on digital rectal examination were entered into the current study from a population‐based prostate cancer screening cohort in Gunma Prefecture, Ja... Mehr ...