Prognostic value of Lynch syndrome, BRAF V600E , and RAS mutational status in dMMR/ MSI‐H metastatic colorectal cancer in a pooled analysis of Dutch and French cohorts
Abstract Background Current knowledge on prognostic biomarkers (especially BRAF V600E / RAS mutations) in metastatic colorectal cancer (mCRC) is mainly based on mCRC patients with proficient mismatch repair (pMMR) tumors. It is uncertain whether these biomarkers have the same prognostic value in mCRC patients with deficient mismatch repair (dMMR) tumors. Methods This observational cohort study combined a population‐based Dutch cohort (2014–2019) and a large French multicenter cohort (2007–2017). All mCRC patients with a histologically proven dMMR tumor were included. Results In our real‐world... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2023 |
Reihe/Periodikum: | Cancer Medicine ; volume 12, issue 15, page 15841-15853 ; ISSN 2045-7634 2045-7634 |
Verlag/Hrsg.: |
Wiley
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Schlagwörter: | Cancer Research / Radiology / Nuclear Medicine and imaging / Oncology |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27079685 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://dx.doi.org/10.1002/cam4.6223 |