Association of vascular amyloid β and cells of the mononuclear phagocyte system in hereditary cerebral hemorrhage with amyloidosis (Dutch) and Alzheimer disease
Arterial and arteriolar amyloid-β (Aβ) deposition in hereditary cerebral hemorrhage with amyloidosis (Dutch) (HCHWA-D) and Alzheimer disease (AD) cerebral amyloid angiopathy (CAA) were studied as to morphology, extent, and association with mononuclear phagocyte system (MPS) cells using Aβ, a- smooth muscle actin, and monocyte/macrophage marker (HLA-DR, CD68, CD11c, CD45) immunohistochemistry. The HCHWA-D/AD arterial/arteriolar media showed compact Aβ deposits, first appearing at the media/adventitia junction, and concomitant smooth muscle loss. Only HCHWA-D CAA featured (a) severe involvement... Mehr ...
Verfasser: |
Maat-Schieman, Marion L.C.
Van Duinen, Sjoerd G.
Rozemuller, Annemieke J.M.
Haan, Joost
Roos, Raymund A.C. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
1997 |
Reihe/Periodikum: |
Maat-Schieman , M L C , Van Duinen , S G , Rozemuller , A J M , Haan , J & Roos , R A C 1997 , ' Association of vascular amyloid β and cells of the mononuclear phagocyte system in hereditary cerebral hemorrhage with amyloidosis (Dutch) and Alzheimer disease ' , Journal of Neuropathology and Experimental Neurology , vol. 56 , no. 3 , pp. 273-284 . https://doi.org/10.1097/00005072-199703000-00006 |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27076737 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vumc.nl/en/publications/c72b1989-7d4a-4abd-bf66-d74354f9b1c9 |