Systemic Therapy in Advanced Nodular Melanoma versus Superficial Spreading Melanoma:A Nation-Wide Study of the Dutch Melanoma Treatment Registry
Nodular melanoma (NM) is associated with a higher locoregional and distant recurrence rate compared with superficial spreading melanoma (SSM); it is unknown whether the efficacy of systemic therapy is limited. Here, we compare the efficacy of immunotherapy and BRAF/MEK inhibitors (BRAF/MEKi) in advanced NM to SSM. Patients with advanced stage IIIc and stage IV NM and SSM treated with anti-CTLA-4 and/or anti-PD-1, or BRAF/MEKi in the first line, were included from the prospective Dutch Melanoma Treatment Registry. The primary objectives were distant metastasis-free survival (DMFS) and overall s... Mehr ...
Verfasser: |
Rauwerdink, Daan Jan Willem
van Doorn, Remco
van der Hage, Jos
van den Eertwegh, Alfonsus J. M.
Haanen, John B. A. G.
Aarts, Maureen
Berkmortel, Franchette
Blank, Christian U.
Boers-Sonderen, Marye J.
de Groot, Jan Willem B.
Hospers, Geke A. P.
de Meza, Melissa
Piersma, Djura
van Rijn, Rozemarijn S.
Stevense, Marion
van der Veldt, Astrid
Vreugdenhil, Gerard
Wouters, Michel W. J. M.
Suijkerbuijk, Karijn
van der Kooij, Monique
Kapiteijn, Ellen |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2022 |
Reihe/Periodikum: |
Rauwerdink , D J W , van Doorn , R , van der Hage , J , van den Eertwegh , A J M , Haanen , J B A G , Aarts , M , Berkmortel , F , Blank , C U , Boers-Sonderen , M J , de Groot , J W B , Hospers , G A P , de Meza , M , Piersma , D , van Rijn , R S , Stevense , M , van der Veldt , A , Vreugdenhil , G , Wouters , M W J M , Suijkerbuijk , K , van der Kooij , M & Kapiteijn , E 2022 , ' Systemic Therapy in Advanced Nodular Melanoma versus Superficial Spreading Melanoma : A Nation-Wide Study of the Dutch Melanoma Treatment Registry ' , Cancers , vol. 14 , no. 22 , 5694 . https://doi.org/10.3390/cancers14225694 |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27076542 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vumc.nl/en/publications/77096530-f7e5-436f-afd0-df126deac3d7 |