A Dutch phase III randomized multicenter trial:Whole brain radiotherapy versus stereotactic radiotherapy for 4-10 brain metastases
Background. The clinical value of whole brain radiotherapy (WBRT) for brain metastases (BM) is a matter of debate due to the significant side effects involved. Stereotactic radiosurgery (SRS) is an attractive alternative treatment option that may avoid these side effects and improve local tumor control. We initiated a randomized trial (NCT02353000) to investigate whether quality of life is better preserved after SRS compared with WBRT in patients with multiple brain metastases. Methods. Patients with 4-10 BM were randomized between the standard arm WBRT (total dose 20 Gy in 5 fractions) or SRS... Mehr ...
Verfasser: |
Hartgerink, Dianne
Bruynzeel, Anna
Eekers, Danielle
Swinnen, Ans
Hurkmans, Coen
Wiggenraad, Ruud
Swaak-Kragten, Annemarie
Dieleman, Edith
Van Der Toorn, Peter Paul
Oei, Bing
Van Veelen, Lieneke
Verhoeff, Joost
Lagerwaard, Frank
De Ruysscher, Dirk
Lambin, Philippe
Zindler, Jaap |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2021 |
Reihe/Periodikum: |
Hartgerink , D , Bruynzeel , A , Eekers , D , Swinnen , A , Hurkmans , C , Wiggenraad , R , Swaak-Kragten , A , Dieleman , E , Van Der Toorn , P P , Oei , B , Van Veelen , L , Verhoeff , J , Lagerwaard , F , De Ruysscher , D , Lambin , P & Zindler , J 2021 , ' A Dutch phase III randomized multicenter trial : Whole brain radiotherapy versus stereotactic radiotherapy for 4-10 brain metastases ' , Neuro-Oncology Advances , vol. 3 , no. 1 , vdab021 . https://doi.org/10.1093/noajnl/vdab021 |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27072115 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://pure.eur.nl/en/publications/5a3e070e-1742-4ad9-abdc-504cd717772e |