Frailty and sarcopenia within the earliest national Dutch childhood cancer survivor cohort (DCCSS-LATER):a cross-sectional study

Verfasser:	van Atteveld, Jenneke E de Winter, Demi T C Pluimakers, Vincent G Fiocco, Marta Nievelstein, Rutger A J Hobbelink, Monique G G Kremer, Leontien C M Grootenhuis, Martha A Maurice-Stam, Heleen Tissing, Wim J E de Vries, Andrica C H Loonen, Jacqueline J van Dulmen-den Broeder, Eline van der Pal, Helena J H Pluijm, Saskia M F van der Heiden-van der Loo, Margriet Versluijs, A Birgitta Louwerens, Marloes Bresters, Dorine van Santen, Hanneke M Hoefer, Imo van den Berg, Sjoerd A A den Hartogh, Jaap Hoeijmakers, Jan H J Neggers, Sebastian J C M M van den Heuvel-Eibrink, Marry M
Dokumenttyp:	Artikel
Erscheinungsdatum:	2023
Reihe/Periodikum:	Dutch LATER study group , van Atteveld , J E , de Winter , D T C , Pluimakers , V G , Fiocco , M , Nievelstein , R A J , Hobbelink , M G G , Kremer , L C M , Grootenhuis , M A , Maurice-Stam , H , Tissing , W J E , de Vries , A C H , Loonen , J J , van Dulmen-den Broeder , E , van der Pal , H J H , Pluijm , S M F , van der Heiden-van der Loo , M , Versluijs , A B , Louwerens , M , Bresters , D , van Santen , H M , Hoefer , I , van den Berg , S A A , den Hartogh , J , Hoeijmakers , J H J , Neggers , S J C M M & van den Heuvel-Eibrink , M M 2023 , ' Frailty and sarcopenia within the earliest national Dutch childhood cancer survivor cohort (DCCSS-LATER) : a cross-sectional study ' , The Lancet Healthy Longevity , vol. 4 , no. 4 , pp. e155-e165 . https://doi.org/10.1016/S2666-7568(23)00020-X
Schlagwörter:	/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache:	Englisch
Permalink:	https://search.fid-benelux.de/Record/base-27072094
Datenquelle:	BASE; Originalkatalog
Powered By:	BASE
Link(s) :	https://pure.eur.nl/en/publications/544143a6-4925-445e-a5e6-67cbb82a06f9

BACKGROUND: Childhood cancer survivors appear to be at increased risk of frailty and sarcopenia, but evidence on the occurrence of and high-risk groups for these aging phenotypes is scarce, especially in European survivors. The aim of this cross-sectional study was to assess the prevalence of and explore risk factors for pre-frailty, frailty, and sarcopenia in a national cohort of Dutch childhood cancer survivors diagnosed between 1963 and 2001. METHODS: Eligible individuals (alive at the time of study, living in the Netherlands, age 18-45 years, and had not previously declined to participate in a late-effects study) from the Dutch Childhood Cancer Survivor Study (DCCSS-LATER) cohort were invited to take part in this cross-sectional study. We defined pre-frailty and frailty according to modified Fried criteria, and sarcopenia according to the European Working Group on Sarcopenia in Older People 2 definition. Associations between these conditions and demographic and treatment-related as well as endocrine and lifestyle-related factors were estimated with two separate multivariable logistic regression models in survivors with any frailty measurement or complete sarcopenia measurements. FINDINGS: 3996 adult survivors of the DCCSS-LATER cohort were invited to participate in this cross-sectional study. 1993 non-participants were excluded due to lack of response or a decline to participate and 2003 (50·1%) childhood cancer survivors aged 18-45 years were included. 1114 (55·6%) participants had complete frailty measurements and 1472 (73·5%) participants had complete sarcopenia measurements. Mean age at participation was 33·1 years (SD 7·2). 1037 (51·8%) participants were male, 966 (48·2%) were female, and none were transgender. In survivors with complete frailty measurements or complete sarcopenia measurements, the percentage of pre-frailty was 20·3% (95% CI 18·0-22·7), frailty was 7·4% (6·0-9·0), and sarcopenia was 4·4% (3·5-5·6). In the models for pre-frailty, underweight (odds ratio [OR] 3·38 [95% CI 1·92-5·95]) and ...