Variation at GRN3′-UTR rs5848 is not associated with a risk of frontotemporal lobar degenerationin Dutch population
Background: A single nucleotide polymorphism (rs5848) located in the 3′- untranslated region of GRN has recently been associated with a risk of frontotemporal lobar degeneration (FTLD) in North American population particularly in pathologically confirmed cases with neural inclusions immunoreactive for ubiquitin and TAR DNA-binding protein 43 (TDP-43), but negative for tau and alpha-synuclein (FTLD-TDP). Methodology/Principal Findings: In an effort to replicate these results in a different population, rs5848 was genotyped in 256 FTLD cases and 1695 controls from the Netherlands. Single SNP gend... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2009 |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-27065498 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://repub.eur.nl/pub/24992 |