We provide an overview of evidence for effective suicide prevention interventions and their significance for the Dutch national agenda for suicide prevention. In 2020, a systematic review reported the effect of preventive interventions on suicide and suicide attempts. This meta-analysis and current developments in the Netherlands are discussed. Sixteen controlled studies with 252,932 participants showed that suicide prevention interventions can prevent suicides and suicide attempts. Multi-level interventions have greater effects than uni-level interventions. It is important that general health care providers improve their skills in recognizing suicide risk. To this end, support by a digital decision support tool as developed in SUPREMOCOL, a recent study evaluating the effectiveness of a system intervention for suicide prevention conducted in the province of Noord-Brabant, can provide a solution. This study showed significant reduction of suicides. However, it is the only scientific study in the Netherlands that explicitly evaluates suicides as outcomes of a suicide prevention intervention. In the Netherlands, scientific research is needed that does just that, in relation to the national suicide prevention agenda. In particular, chain interventions in which the connection is made between the identification of people with suicide risk at population level and access to specialist care, deserve priority.