Has the Rate of CD4 Cell Count Decline before Initiation of Antiretroviral Therapy Changed over the Course of the Dutch HIV Epidemic among MSM?

Introduction:Studies suggest that the HIV-1 epidemic in the Netherlands may have become more virulent, leading to faster disease progression if untreated. Analysis of CD4 cell count decline before antiretroviral therapy (ART) initiation, a surrogate marker for disease progression, may be hampered by informative censoring as ART initiation is more likely with a steeper CD4 cell count decline.Methods:Development of CD4 cell count from 9 to 48 months after seroconversion was analyzed using a mixed-effects model and 2 models that jointly modeled CD4 cell counts and time to censoring event (start A... Mehr ...

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Verfasser: Gras, Luuk
Geskus, Ronald B.
Jurriaans, Suzanne
Bakker, Margreet
van Sighem, Ard
Bezemer, Daniela
Fraser, Christophe
Prins, Jan M.
Berkhout, Ben
Prins, J.M.
Kuijpers, T.W.
Scherpbier, H.J.
Boer, K.
van der Meer, J.T.M.
Wit, F.W.M.N.
Godfried, M.H.
Reiss, P.
van der Poll, T.
Nellen, F.J.B.
Lange, J.M.A.
Geerlings, S.E.
van Vugt, M.
Vrouenraets, S.M.E.
Pajkrt, D.
Bos, J.C.
van der Valk, M.
Schreij, G.
Lowe, S.
Oude Lashof, A.
Pronk, M.J.H.
Bravenboer, B.
van der Ende, M.E.
de Vries-Sluijs, T.E.M.S.
Schurink, C.A.M.
van der Feltz, M.
Nouwen, J.L.
Gelinck, L.B.S.
Verbon, A.
Rijnders, B.J.A.
van de Ven-de Ruiter, E.D.
Slobbe, L.
Kauffmann, R.H.
Schippers, E.F.
Groeneveld, P.H.P.
Alleman, M.A.
Bouwhuis, J.W.
ten Kate, R.W.
Soetekouw, R.
Kroon, F.P.
van den Broek, P.J.
van Dissel, J.T.
Arend, S.M.
van Nieuwkoop, C.
de Boer, M.G.J.
Jolink, H.
den Hollander, J.G.
Pogany, K.
Bronsveld, W.
Kortmann, W.
van Twillert, G.
van Houte, D.P.F.
Polée, M.B.
van Vonderen, M.G.A.
ten Napel, C.H.H.
Kootstra, G.J.
Brinkman, K.
Blok, W.L.
Frissen, P.H.J.
Schouten, W.E.M.
van den Berk, G.E.L.
Juttmann, J.R.
van Kasteren, M.E.E.
Brouwer, A.E.
Mulder, J.W.
van Gorp, E.C.M.
Smit, P.M.
Weijer, S.
van Eeden, A.
Verhagen, D.W.M.
Sprenger, H.G.
Doedens, R.
Scholvinck, E.H.
van Assen, S.
Stek, C.J.
Hoepelman, I.M.
Mudrikova, T.
Schneider, M.M.E.
Jaspers, C.A.J.J.
Ellerbroek, P.M.
Peters, E.J.G.
Maarschalk-Ellerbroek, L.J.
Oosterheert, J.J.
Arends, J.E.
Wassenberg, M.W.M.
van der Hilst, J.C.H.
Richter, C.
van der Berg, J.P.
Gisolf, E.H.
Dokumenttyp: Artikel
Erscheinungsdatum: 2013
Reihe/Periodikum: Gras , L , Geskus , R B , Jurriaans , S , Bakker , M , van Sighem , A , Bezemer , D , Fraser , C , Prins , J M , Berkhout , B , Prins , J M , Kuijpers , T W , Scherpbier , H J , Boer , K , van der Meer , J T M , Wit , F W M N , Godfried , M H , Reiss , P , van der Poll , T , Nellen , F J B , Lange , J M A , Geerlings , S E , van Vugt , M , Vrouenraets , S M E , Pajkrt , D , Bos , J C , van der Valk , M , Schreij , G , Lowe , S , Oude Lashof , A , Pronk , M J H , Bravenboer , B , van der Ende , M E , de Vries-Sluijs , T E M S , Schurink , C A M , van der Feltz , M , Nouwen , J L , Gelinck , L B S , Verbon , A , Rijnders , B J A , van de Ven-de Ruiter , E D , Slobbe , L , Kauffmann , R H , Schippers , E F , Groeneveld , P H P , Alleman , M A , Bouwhuis , J W , ten Kate , R W , Soetekouw , R , Kroon , F P , van den Broek , P J , van Dissel , J T , Arend , S M , van Nieuwkoop , C , de Boer , M G J , Jolink , H , den Hollander , J G , Pogany , K , Bronsveld , W , Kortmann , W , van Twillert , G , van Houte , D P F , Polée , M B , van Vonderen , M G A , ten Napel , C H H , Kootstra , G J , Brinkman , K , Blok , W L , Frissen , P H J , Schouten , W E M , van den Berk , G E L , Juttmann , J R , van Kasteren , M E E , Brouwer , A E , Mulder , J W , van Gorp , E C M , Smit , P M , Weijer , S , van Eeden , A , Verhagen , D W M , Sprenger , H G , Doedens , R , Scholvinck , E H , van Assen , S , Stek , C J , Hoepelman , I M , Mudrikova , T , Schneider , M M E , Jaspers , C A J J , Ellerbroek , P M , Peters , E J G , Maarschalk-Ellerbroek , L J , Oosterheert , J J , Arends , J E , Wassenberg , M W M , van der Hilst , J C H , Richter , C , van der Berg , J P & Gisolf , E H 2013 , ' Has the Rate of CD4 Cell Count Decline before Initiation of Antiretroviral Therapy Changed over the Course of the Dutch HIV Epidemic among MSM? ' , PLoS ONE , vol. 8 , no. 5 , e64437 . https://doi.org/10.1371/journal.pone.0064437
Schlagwörter: antiretrovirus agent / virus RNA / adolescent / adult / analytical parameters / antiviral therapy / article / CD4 lymphocyte count / disease course / drug efficacy / epidemic / human / human cell / Human immunodeficiency virus 1 / Human immunodeficiency virus infection / major clinical study / male / men who have sex with men / Netherlands / seroconversion
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-27059805
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://hdl.handle.net/11370/e54fed71-500d-4e56-b940-b3bf888d2aca

Introduction:Studies suggest that the HIV-1 epidemic in the Netherlands may have become more virulent, leading to faster disease progression if untreated. Analysis of CD4 cell count decline before antiretroviral therapy (ART) initiation, a surrogate marker for disease progression, may be hampered by informative censoring as ART initiation is more likely with a steeper CD4 cell count decline.Methods:Development of CD4 cell count from 9 to 48 months after seroconversion was analyzed using a mixed-effects model and 2 models that jointly modeled CD4 cell counts and time to censoring event (start ART