Frailty and sarcopenia within the earliest national Dutch childhood cancer survivor cohort (DCCSS-LATER):a cross-sectional study

Verfasser:	van Atteveld, Jenneke E. de Winter, Demi T.C. Pluimakers, Vincent G. Fiocco, Marta Nievelstein, Rutger A.J. Hobbelink, Monique G.G. Kremer, Leontien C.M. Grootenhuis, Martha A. Maurice-Stam, Heleen Tissing, Wim J.E. de Vries, Andrica C.H. Loonen, Jacqueline J. van Dulmen-den Broeder, Eline van der Pal, Helena J.H. Pluijm, Saskia M.F. van der Heiden-van der Loo, Margriet Versluijs, A. Birgitta Louwerens, Marloes Bresters, Dorine van Santen, Hanneke M. Hoefer, Imo van den Berg, Sjoerd A.A. den Hartogh, Jaap Hoeijmakers, Jan H.J. Neggers, Sebastian J.C.M.M. van den Heuvel-Eibrink, Marry M.
Dokumenttyp:	Artikel
Erscheinungsdatum:	2023
Reihe/Periodikum:	Dutch LATER Study Group , van Atteveld , J E , de Winter , D T C , Pluimakers , V G , Fiocco , M , Nievelstein , R A J , Hobbelink , M G G , Kremer , L C M , Grootenhuis , M A , Maurice-Stam , H , Tissing , W J E , de Vries , A C H , Loonen , J J , van Dulmen-den Broeder , E , van der Pal , H J H , Pluijm , S M F , van der Heiden-van der Loo , M , Versluijs , A B , Louwerens , M , Bresters , D , van Santen , H M , Hoefer , I , van den Berg , S A A , den Hartogh , J , Hoeijmakers , J H J , Neggers , S J C M M & van den Heuvel-Eibrink , M M 2023 , ' Frailty and sarcopenia within the earliest national Dutch childhood cancer survivor cohort (DCCSS-LATER) : a cross-sectional study ' , The Lancet Healthy Longevity , vol. 4 , no. 4 , pp. e155-e165 . https://doi.org/10.1016/S2666-7568(23)00020-X
Sprache:	Englisch
Permalink:	https://search.fid-benelux.de/Record/base-27059744
Datenquelle:	BASE; Originalkatalog
Powered By:	BASE
Link(s) :	https://hdl.handle.net/11370/dcf2600d-36e3-46a7-acac-876c4c0d6d8c

Background: Childhood cancer survivors appear to be at increased risk of frailty and sarcopenia, but evidence on the occurrence of and high-risk groups for these aging phenotypes is scarce, especially in European survivors. The aim of this cross-sectional study was to assess the prevalence of and explore risk factors for pre-frailty, frailty, and sarcopenia in a national cohort of Dutch childhood cancer survivors diagnosed between 1963 and 2001. Methods: Eligible individuals (alive at the time of study, living in the Netherlands, age 18–45 years, and had not previously declined to participate in a late-effects study) from the Dutch Childhood Cancer Survivor Study (DCCSS-LATER) cohort were invited to take part in this cross-sectional study. We defined pre-frailty and frailty according to modified Fried criteria, and sarcopenia according to the European Working Group on Sarcopenia in Older People 2 definition. Associations between these conditions and demographic and treatment-related as well as endocrine and lifestyle-related factors were estimated with two separate multivariable logistic regression models in survivors with any frailty measurement or complete sarcopenia measurements. Findings: 3996 adult survivors of the DCCSS-LATER cohort were invited to participate in this cross-sectional study. 1993 non-participants were excluded due to lack of response or a decline to participate and 2003 (50·1%) childhood cancer survivors aged 18–45 years were included. 1114 (55·6%) participants had complete frailty measurements and 1472 (73·5%) participants had complete sarcopenia measurements. Mean age at participation was 33·1 years (SD 7·2). 1037 (51·8%) participants were male, 966 (48·2%) were female, and none were transgender. In survivors with complete frailty measurements or complete sarcopenia measurements, the percentage of pre-frailty was 20·3% (95% CI 18·0–22·7), frailty was 7·4% (6·0–9·0), and sarcopenia was 4·4% (3·5–5·6). In the models for pre-frailty, underweight (odds ratio [OR] 3·38 [95% CI 1·92–5·95]) and ...