Dutch pharmacogenetics working group (DPWG) guideline for the gene–drug interaction between UGT1A1 and irinotecan
The Dutch Pharmacogenetics Working Group (DPWG) aims to facilitate PGx implementation by developing evidence-based pharmacogenetics guidelines to optimize pharmacotherapy. This guideline describes the starting dose optimization of the anti-cancer drug irinotecan to decrease the risk of severe toxicity, such as (febrile) neutropenia or diarrhoea. Uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1 encoded by the UGT1A1 gene) enzyme deficiency increases risk of irinotecan-induced toxicity. Gene variants leading to UGT1A1 enzyme deficiency (e.g. UGT1A1*6, *28 and *37) can be used to optimize... Mehr ...
Verfasser: |
Hulshof, Emma C.
Deenen, Maarten J.
Nijenhuis, Marga
Soree, Bianca
de Boer-Veger, Nienke J.
Buunk, Anne Marie
Houwink, Elisa J.F.
Risselada, Arne
Rongen, Gerard A.P.J.M.
van Schaik, Ron H.N.
Touw, Daan J.
van der Weide, Jan
van Westrhenen, Roos
Deneer, Vera H.M.
Guchelaar, Henk Jan
Swen, Jesse J. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2023 |
Reihe/Periodikum: |
Hulshof , E C , Deenen , M J , Nijenhuis , M , Soree , B , de Boer-Veger , N J , Buunk , A M , Houwink , E J F , Risselada , A , Rongen , G A P J M , van Schaik , R H N , Touw , D J , van der Weide , J , van Westrhenen , R , Deneer , V H M , Guchelaar , H J & Swen , J J 2023 , ' Dutch pharmacogenetics working group (DPWG) guideline for the gene–drug interaction between UGT1A1 and irinotecan ' , European Journal of Human Genetics , vol. 31 , pp. 982–987 . https://doi.org/10.1038/s41431-022-01243-2 |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-27059498 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://hdl.handle.net/11370/c9aec2f0-5317-4714-a084-f6d0c19fe748 |