HLA class II alleles of susceptibility and protection in Brazilian and Dutch pemphigus foliaceus
Pemphigus foliaceus (PF) is a worldwide chronic autoimmune bullous disease targeting desmoglein 1 (Dsg 1) on epithelial cell surface of skin and mucous membranes, causing lesions in skin but sparing mucosa, since the latter contain compensating desmoglein 3(1) . Several environmental triggers for the autoimmune reaction have been imputed, such as drugs, ultraviolet radiation and mercurium. Human leucocyte antigens class II (HLA-DR4) alleles were linked to the disease in Ashkenazi Jews and other populations(2) . For endemic pemphigus foliaceus in Brazil, named fogo selvagem (FS), HLA-DRB1*04 wa... Mehr ...
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| Dokumenttyp: | Artikel |
| Erscheinungsdatum: | 2018 |
| Reihe/Periodikum: | de Sena Nogueira Maehara , L , De-Souza-Santana , F C , Porro , A M , Marcos , E V C , Ura , S , Nolte , I M , Pas , H H , Jonkman , M F & Tomimori , J 2018 , ' HLA class II alleles of susceptibility and protection in Brazilian and Dutch pemphigus foliaceus ' , The British journal of dermatology , vol. 178 , no. 3 , pp. e212-e214 . https://doi.org/10.1111/bjd.16022 |
| Schlagwörter: | Letter / VULGARIS / GENETICS / FOGO-SELVAGEM |
| Sprache: | Englisch |
| Permalink: | https://search.fid-benelux.de/Record/base-27058615 |
| Datenquelle: | BASE; Originalkatalog |
| Powered By: | BASE |
| Link(s) : | https://hdl.handle.net/11370/554c615a-8240-43da-8eb4-e1023f636eea |
Pemphigus foliaceus (PF) is a worldwide chronic autoimmune bullous disease targeting desmoglein 1 (Dsg 1) on epithelial cell surface of skin and mucous membranes, causing lesions in skin but sparing mucosa, since the latter contain compensating desmoglein 3(1) . Several environmental triggers for the autoimmune reaction have been imputed, such as drugs, ultraviolet radiation and mercurium. Human leucocyte antigens class II (HLA-DR4) alleles were linked to the disease in Ashkenazi Jews and other populations(2) . For endemic pemphigus foliaceus in Brazil, named fogo selvagem (FS), HLA-DRB1*04 was shown to have a relative risk >14 for the disease(3) . This article is protected by copyright. All rights reserved.